{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:37:53Z","timestamp":1780335473687,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study assessed whether continued treatment with anti\u2010CGRP monoclonal antibodies (mAbs) is driven more by reductions in monthly migraine days (MMDs) or patients' global impression of change (PGIC), a patient\u2010reported outcome. Among 169 patients treated with anti\u2010CGRP mAbs, 21.3% discontinued due to ineffectiveness. PGIC responders (\u2265\u20095) at month 12 were 69.8%, whereas MMD responders (\u2265\u200950% reduction) were 59.2%. Both were significantly associated with discontinuation (PGIC: <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200933.474, <jats:italic>\u03c6<\/jats:italic>\u2009=\u20090.445; MMD: <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200929.884, <jats:italic>\u03c6<\/jats:italic>\u2009=\u20090.421; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). PGIC showed a stronger correlation with discontinuation (<jats:italic>r<\/jats:italic><jats:sub>pb<\/jats:sub>\u2009=\u20090.541) than MMD reduction (<jats:italic>r<\/jats:italic><jats:sub>pb<\/jats:sub>\u2009=\u20090.470). These findings highlight PGIC as strongly associated with treatment response, supporting the need for PROMs in evaluating migraine treatment effectiveness.<\/jats:p>","DOI":"10.1002\/acn3.70053","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T16:57:21Z","timestamp":1744909041000},"page":"1292-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patients' Global Impression of Change (<scp>PGIC<\/scp>) Score Compared to Monthly Migraine Days to Evaluate Treatment Persistence With Anti\u2010<scp>CGRP<\/scp> Monoclonal Antibodies"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-3141","authenticated-orcid":false,"given":"Marina","family":"Romozzi","sequence":"first","affiliation":[{"name":"Dipartimento Universitario di Neuroscienze Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catello","family":"Vollono","sequence":"additional","affiliation":[{"name":"Dipartimento Universitario di Neuroscienze Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0326-5509","authenticated-orcid":false,"given":"Paolo","family":"Calabresi","sequence":"additional","affiliation":[{"name":"Dipartimento Universitario di Neuroscienze Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome 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