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We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14\u2009years, finding that NfL demonstrates high prognostic value and distinct longitudinal dynamics in premanifest\/transitional HD. Here, we report the corresponding results for serum glial fibrillary acidic protein and total tau, providing the first longitudinal and head\u2010to\u2010head study of these biomarkers in HD. 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