{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:46:51Z","timestamp":1773971211995,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000098","name":"Clinical Center","doi-asserted-by":"publisher","award":["6S10OD012297\u201002"],"award-info":[{"award-number":["6S10OD012297\u201002"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RG\u20101901\u201033190"],"award-info":[{"award-number":["RG\u20101901\u201033190"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007217","name":"Health Services Research and Development","doi-asserted-by":"publisher","award":["I01CX002160\u201001A1"],"award-info":[{"award-number":["I01CX002160\u201001A1"]}],"id":[{"id":"10.13039\/100007217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PRLs were identified on susceptibility weighted imaging (SWI) of 68\u00a0newly diagnosed patients. Each PRL was paired with an anatomically matched contralateral non\u2010PRL (nPRL) from the same participant. Quantitative magnetization transfer imaging derived macromolecular\u2010to\u2010free pool\u2010size ratio (PSR) and relaxation rate of the free water pool (R\n                      <jats:sub>1f<\/jats:sub>\n                      ) values were extracted and compared between PRLs and nPRLs, NAWM surrounding PRLs and nPRLs, and whole brain WM lesions and NAWM of PRL+ and PRL\u2212 people with MS (pwMS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PSR and R\n                      <jats:sub>1f<\/jats:sub>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.028) values were lower in PRLs compared to nPRLs, but there were no differences in PSR and R\n                      <jats:sub>1f<\/jats:sub>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2265\u20090.824) values between peri\u2010PRLs and peri\u2010nPRLs NAWM ROIs. PRL+ pwMS had similar PSR and R\n                      <jats:sub>1f<\/jats:sub>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2265\u20090.267) of the whole brain NAWM, similar WM lesions PSR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.764) but lower R\n                      <jats:sub>1f<\/jats:sub>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the early stages of MS, there is no association between PRLs and surrounding NAWM degree of injury.<\/jats:p>\n                  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