{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:49:57Z","timestamp":1758476997199,"version":"3.43.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS113757"],"award-info":[{"award-number":["NS113757"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This case described a 25\u2010year\u2010old pregnant woman with refractory multifocal epilepsy, diagnosed in 2020 and treated with bilateral thalamic deep brain stimulation (DBS) targeting the centromedian and pulvinar nuclei. Prior to DBS, she experienced daily focal seizures, often progressing to generalized tonic\u2013clonic seizures despite optimal medication. Presurgical evaluations revealed multifocal epilepsy with right hemispheric involvement and diffuse band heterotopia. Given the extensive neurophysiological and radiographic findings, DBS was chosen over resective surgery. Following implantation in December 2023, initial stimulation settings resulted in some seizure control but also development of new symptoms, including shock\u2010like sensations down her neck. After 43 seizure\u2010free days, she experienced a prolonged seizure in April 2024, prompting further investigation. Imaging revealed migration of the right pulvinar electrode, which was identified as the likely cause. This resultant displacement, called the \u201cTwiddler's Syndrome,\u201d is a phenomenon where device manipulation causes malfunction or dislodgment. This resulted from the patient's habit of massaging her neck. After adjusting DBS settings and turning off right pulvinar stimulation, her symptoms resolved, and she remained seizure\u2010free for two months. This case emphasizes the need for careful postimplantation monitoring, imaging, and awareness of hardware\u2010related issues like Twiddler's Syndrome, highlighting the importance of well\u2010planned surgical strategies to optimize outcomes in neuromodulation therapies.<\/jats:p>","DOI":"10.1002\/acn3.70109","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T10:11:09Z","timestamp":1751191869000},"page":"1711-1716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Systematic Clinical Framework for Postimplantation Monitoring in Thalamic Neuromodulation: Insights From Twiddler's Syndrome"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6255-3616","authenticated-orcid":false,"given":"Shalin","family":"Shah","sequence":"first","affiliation":[{"name":"McGovern Medical School University of Texas Health Science Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganne","family":"Chaitanya","sequence":"additional","affiliation":[{"name":"Texas Institute for Restorative Neurotechnologies, Department of Neurology University of Texas Health Science Center  Houston Texas USA"},{"name":"Department of Neurology University of Texas Health Science Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5042-5018","authenticated-orcid":false,"given":"Jeston","family":"Chin","sequence":"additional","affiliation":[{"name":"Texas Institute for Restorative Neurotechnologies, Department of Neurology University of Texas Health Science Center  Houston Texas USA"},{"name":"Department of Neurology University of Texas Health Science Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Delcimmuto","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Texas Health Science Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay R.","family":"Gavvala","sequence":"additional","affiliation":[{"name":"Texas Institute for Restorative Neurotechnologies, Department of Neurology University of Texas Health Science Center  Houston Texas USA"},{"name":"Department of Neurology University of Texas Health Science Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00601"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.10.JNS131225"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10159"},{"issue":"8","key":"e_1_2_9_5_1","first-page":"371","article-title":"The Pacemaker\u2010Twiddler's Syndrome: A New Complication of Implantable Transvenous Pacemakers","volume":"99","author":"Bayliss C. 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