{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:05:03Z","timestamp":1789185903531,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["TA\u20102006\u201036695"],"award-info":[{"award-number":["TA\u20102006\u201036695"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bladder dysfunction affects over 85% of people with multiple sclerosis (PwMS), yet current assessment methods are limited to periodic in\u2010clinic evaluations or subjective patient reports, failing to capture real\u2010world symptom fluctuations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the feasibility and validity of using a novel remote bladder ultrasound device for home monitoring of bladder dysfunction in PwMS, comparing remote measurements with standard clinical assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010two women with MS participated in this 3\u2010month pilot study. Participants were asked to use the wearable ultrasound device at home for at least 3\u20135\u2009days a month. Remote device measurements were compared with standard clinical data for post\u2010void residual (rPVR vs. cPVR) and urinary frequency (rFrequency vs. 3\u2010day bladder diary frequency). Agreement between measures was assessed using Bland\u2013Altman analyses and correlation coefficients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants were middle\u2010aged (mean 51.5\u2009years; SD 9.3) with mild\u2013moderate disability (median EDSS 4.0) and mostly relapsing MS (72.7%). Study retention was high (86.4%; 19\/22), with mean device utilization of 14.1\u2009days. Good agreement was seen between rPVR and cPVR (mean difference\u2009=\u200932.1\u2009mL, SD\u2009=\u200938.6; 95% limits of agreement: \u221243.6, 107.9). The rFrequency measure also demonstrated a strong correlation with patient\u2010reported frequency (ICC\u2009=\u20090.81, Pearson's <jats:italic>r<\/jats:italic>\u2009=\u20090.793, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Visualization of remote monitoring data revealed substantial day\u2010to\u2010day variability in bladder symptoms not captured by traditional assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This pilot study demonstrates the feasibility and preliminary validity of using wearable ultrasound technology for remote monitoring of bladder dysfunction in PwMS. The ability to capture real\u2010world symptom variations could transform assessment and management approaches, enabling more personalized and responsive care strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.70112","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T12:40:01Z","timestamp":1753188001000},"page":"1865-1874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Continuous Monitoring of Bladder Dysfunction in People With Multiple Sclerosis: Wearables for the Bladder"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6199-5484","authenticated-orcid":false,"given":"Valerie J.","family":"Block","sequence":"first","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California San Francisco  San Francisco California USA"},{"name":"Department of Physical Therapy and Rehabilitation Science University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-151X","authenticated-orcid":false,"given":"Shane","family":"Poole","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Science University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7270-595X","authenticated-orcid":false,"given":"Nikki","family":"Sisodia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelyn","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabby","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle E.","family":"Van Kuiken","sequence":"additional","affiliation":[{"name":"Department of Urology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Suskind","sequence":"additional","affiliation":[{"name":"Department of Urology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley","family":"Bove","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2016.53"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52001-2.00011-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11884-012-0129-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-012-0266-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516633903"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073.2016-006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-011-0820-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073.2023-108"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_9_13_1","volume-title":"Bladder Post Void Residual Volume","author":"Ballstaedt L.","year":"2020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163847"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.2015.19.4.272"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22530"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1179\/2045772315Y.0000000021"},{"key":"e_1_2_9_18_1","first-page":"9","volume-title":"Wearables for the Bladder: Stakeholder Perspectives on Moving MS Bladder Dysfunction Into the 21st Century","author":"Block V. 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