{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:00:29Z","timestamp":1793826029731,"version":"4.6.1"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the utility of smartwatch and smartphone\u2010based activity metrics for assessing disease severity and quality of life in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the electronic monitoring of disease activity in patients with CIDP (EMDA\u2010CIDP) trial, we performed a prospective observational study from January 2023 to July 2024 at university hospitals in D\u00fcsseldorf and M\u00fcnster, with an independent validation cohort in Hannover. Eligible participants were adults with CIDP on stable intravenous immunoglobulin (IVIG) therapy. Clinical evaluations included established disability scales (I\u2010RODS and INCAT) and quality of life assessments. Activity metrics were captured via consumer\u2010grade smartwatches, with adherence criteria applied to ensure data quality. A real\u2010world smartphone\u2010based cohort of 20 patients was used as a comparator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 46 participants (median age 64\u2009Years [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 57\u201369]; 24% female), smartwatch\u2010derived maximum daily\u2010step count emerged as a robust indicator of disease severity. In 43 patients meeting wearable adherence criteria, maximum daily steps showed strong correlations with clinical scores, positively with I\u2010<jats:styled-content style=\"fixed-case\">RODS<\/jats:styled-content> (Spearman's <jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.74) and inversely with <jats:styled-content style=\"fixed-case\">INCAT<\/jats:styled-content> (Spearman's <jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u22120.54). Additional smartwatch metrics correlated with quality of life domains, whereas smartphone\u2010derived metrics of a validation cohort exhibited weaker correlations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>These results indicate that smartwatches many patients already use can yield valuable, objective data for assessing disease status in CIDP. Integrating smartwatch\u2010derived metrics into clinical assessments may enhance traditional evaluations and deepen understanding of disease progression and patient quality of life. These promising results warrant additional, larger\u2010scale studies in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.70137","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T05:14:07Z","timestamp":1752124447000},"page":"2045-2055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-1415","authenticated-orcid":false,"given":"Lars","family":"Masanneck","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital and Medical Faculty University Hospital D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Hasso Plattner Institute, Digital Engineering Faculty University of Potsdam  Potsdam 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