{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:11:48Z","timestamp":1789161108641,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to investigate the comparative effectiveness of standard versus personalized extended interval dosing of anti\u2010CD20 therapy on clinical and sub\u2010clinical outcomes in multiple sclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical information was collected prospectively on Research Electronic Data Capture. Patients with age \u2265\u200918\u2009years old, confirmed diagnosis of multiple sclerosis, treatment with B\u2010cell depleting drug (Rituximab and Ocrelizumab), and minimum follow\u2010up of 12\u2009months with at least 3 clinical visits and at least 3 infusions of medication were included and divided into an extended interval dosing group, a standard interval dosing group, and a converters group who switched from standard to extended interval dosing. Retinal measures were obtained using spectral domain Optical Coherence Tomography. Magnetic resonance imaging acquisitions were performed in two centers using a standardized conventional imaging protocol for multiple sclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients had a median clinical follow\u2010up of 3.5 (0.44\u20137.3) years, retinal OCT follow\u2010up of 2.6 (1.4) years, and MRI follow\u2010up of 2.6 (1.1) years. Annualized changes in clinical measures, retinal measures, and brain volumetric measures were similar between the 3 groups. Multivariate regression analyses also showed no differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>We found no differences in clinical or sub\u2010clinical outcomes between patients treated with standard interval dosing, patients converting from standard to extended interval dosing, and patients on extended interval dosing of B\u2010cell depleting drugs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.70142","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T01:46:12Z","timestamp":1752716772000},"page":"2086-2096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative Effect of Standard Versus Extended Interval Dosing of Rituximab or Ocrelizumab in Multiple Sclerosis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0476-0990","authenticated-orcid":false,"given":"Nabil K.","family":"El Ayoubi","sequence":"first","affiliation":[{"name":"Nehme and Therese Tohme Multiple Sclerosis Center, Department of Neurology American University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fares","family":"Fahd","sequence":"additional","affiliation":[{"name":"Department of Neurology American University of Beirut and Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Tamim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinical Research Institute American University of Beirut Medical Center  Beirut Lebanon"},{"name":"College of Medicine, Alfaisal University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-3242","authenticated-orcid":false,"given":"Salem","family":"Hannoun","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences American University of 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