{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:00:53Z","timestamp":1787508053185,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004856","name":"New York State Department of Health","doi-asserted-by":"publisher","award":["C34462GG"],"award-info":[{"award-number":["C34462GG"]}],"id":[{"id":"10.13039\/100004856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Repetitive transcranial magnetic stimulation (rTMS) is a non\u2010invasive brain stimulation strategy with a demonstrated potential to reinforce the residual pathways after a spinal cord injury (SCI). A preclinically tested high\u2010frequency (15\u2009Hz) rTMS (15\u2009Hz rTMS) protocol was shown to induce corticospinal tract axon regeneration growth and sprouting, resulting in improved voluntary motor control and performance. In a translational perspective, we aimed to investigate the safety and feasibility of the 15\u2009Hz rTMS paradigm as an adjunct therapeutic intervention in individuals with chronic SCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We thus investigated the effects of a 15\u2010day repeated protocol consisting of 15\u2009Hz rTMS followed by task\u2010specific hand motor training in 7 individuals with chronic cervical SCI. 15\u2009Hz rTMS targeted the weaker wrist extensor muscle, based on participant\u2010 and day\u2010specific resting motor threshold, motor responses, and maximum tolerability. Safety, feasibility, neurophysiological, and clinical functional outcomes were measured at different times of the therapeutic protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The therapeutic stimulation protocol was delivered mostly as designed except with regard to stimulation intensity and duration and was overall tolerable without major serious effects. Preliminary neuroplastic and functional benefits revealed by corticospinal excitability and intracortical inhibition modulation and clinical improvements were noted and were still observable at follow\u2010up times.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>This study confirms that an intervention combining 15\u2009Hz rTMS and task\u2010specific motor training is feasible, tolerable, and has the potential to induce neuroplastic changes and improve function in individuals with chronic cervical SCI. This feasibility study, in parallel with previous reports in able\u2010bodied individuals, warrants further investigation of the adapted 15\u2009Hz rTMS protocol in individuals at an earlier stage post\u2010injury and to confirm efficacy in a larger and controlled study trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70154","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T06:43:31Z","timestamp":1754549011000},"page":"2246-2257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Translating a Preclinically Tested 15\u2009Hz\n                    <scp>rTMS<\/scp>\n                    Protocol to Humans With Chronic Spinal Cord Injury: A Safety and Feasibility Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2862-8356","authenticated-orcid":false,"given":"Nabila","family":"Brihmat","sequence":"first","affiliation":[{"name":"Tim and Caroline Reynolds Center for Spinal Stimulation Kessler Foundation  West Orange New Jersey USA"},{"name":"Department of Physical Medicine &amp; Rehabilitation Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmed B.","family":"Bayram","sequence":"additional","affiliation":[{"name":"Tim and Caroline Reynolds Center for Spinal Stimulation Kessler Foundation  West Orange New Jersey USA"},{"name":"Department of Physical Medicine &amp; Rehabilitation Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Paine","sequence":"additional","affiliation":[{"name":"Tim and Caroline Reynolds Center for Spinal Stimulation Kessler Foundation  West Orange New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle","family":"Carnahan","sequence":"additional","affiliation":[{"name":"Tim and Caroline Reynolds Center for Spinal Stimulation Kessler Foundation  West Orange New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhong","sequence":"additional","affiliation":[{"name":"Burke Neurological Institute  White Plains New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Guan","sequence":"additional","affiliation":[{"name":"Burke Neurological Institute  White Plains New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang H.","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Center for Mobility &amp; Rehabilitation Engineering Research Kessler Foundation  West Orange New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Movement Sciences Rutgers School of Health Professions  Newark New Jersey USA"},{"name":"Department of Neurology Robert Wood Johnson Medical School (RWJMS)  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail F.","family":"Forrest","sequence":"additional","affiliation":[{"name":"Tim and Caroline Reynolds Center for Spinal Stimulation Kessler Foundation  West Orange New Jersey USA"},{"name":"Department of Physical Medicine &amp; Rehabilitation Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Burke Neurological Institute  White Plains New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30287-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7473"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.800349"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.07.418"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2014.00042"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101613"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.04.022"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2014.136"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz290"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/err.err_48_18"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09593985.2020.1802797"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6751-10.2011"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.931601"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-150634"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.09.028"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq6885"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-04879-6"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-2-40"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00268.2022"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-5597(97)00096-8"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-980X(97)00036-2"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.02.002"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzaa006"},{"issue":"1","key":"e_1_2_11_25_1","article-title":"Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression on Behalf of Both the National Network of Depression Centers rTMS Task Group and the American Psychiatric Associat","volume":"79","author":"Mcclintock S. 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