{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:03:50Z","timestamp":1776787430119,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["113\u2010CTC0023"],"award-info":[{"award-number":["113\u2010CTC0023"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["114\u2010S0168"],"award-info":[{"award-number":["114\u2010S0168"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Despite celecoxib, a cyclooxygenase\u20102 inhibitor, promoting functional recovery from intracerebral hemorrhage (ICH) by reducing inflammation\u2010mediated perihematomal edema in rat models, the evidence of its effects on patient outcomes remains limited. As nonsteroidal anti\u2010inflammatory drugs (NSAIDs) alleviate inflammation by inhibiting cyclooxygenase\u20102, this study aimed to assess the impact of non\u2010aspirin NSAIDs on ICH outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with acute ICH admitted to our hospital between January 2015 and December 2020 were prospectively enrolled and retrospectively categorized based on pre\u2010 or post\u2010ICH use of non\u2010aspirin NSAIDs. Outcomes were assessed using the modified Rankin Scale (mRS) score at 3\u2009months, survival at 1\u2009year, and mortality at long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 976 patients with acute ICH, 2.0% and 15.0% were non\u2010aspirin NSAID users before and after ICH, respectively. Post\u2010ICH non\u2010aspirin NSAID use was associated with a reduced 1\u2010year mortality risk (adjusted odds ratio [aOR] 0.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and long\u2010term mortality risk (adjusted hazard ratio 0.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043), but not good functional outcomes (mRS 0\u20132) (aOR 0.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.940). In the subgroup analyses, post\u2010ICH use might be linked to good functional outcomes in patients with lobar hemorrhage or in those without surgical intervention. Pre\u2010ICH non\u2010aspirin NSAID use was not associated with these outcomes in the overall population, but it might be linked to increased mortality in subgroups with lobar hemorrhage, cerebral amyloid angiopathy, hyperlipidemia, or without intraventricular hemorrhage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The post\u2010ICH use of non\u2010aspirin NSAIDs reduced mortality. Future studies are warranted to identify specific non\u2010aspirin NSAID regimens that can significantly improve the outcomes of patients with ICH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70163","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T06:25:49Z","timestamp":1755325549000},"page":"2328-2334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Non\u2010Aspirin Nonsteroidal Anti\u2010Inflammatory Drugs on Acute Intracerebral Hemorrhage"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-6295","authenticated-orcid":false,"given":"Shin\u2010Joe","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-5973","authenticated-orcid":false,"given":"Sung\u2010Chun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Kai","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiann\u2010Shing","family":"Jeng","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319949"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105948"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005167"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010054"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303160"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000130866.25040.7D"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12140"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.12.020"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-024-01996-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.18433\/J3T886"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.497040"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-020-01022-1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011678"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03798.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.4.891"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.661603"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-016-0546-y"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0277296"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12628"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.911207"},{"key":"e_1_2_10_22_1","first-page":"84","article-title":"Improvement After Celecoxib Treatment in Patients With Thalamic Hemorrhage\u2014A Case Report","volume":"31","author":"Lin Y. 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