{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:06:46Z","timestamp":1787501206452,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471036"],"award-info":[{"award-number":["32471036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n Recurrent high\u2010grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of\n SYHA1813<\/jats:styled-content>\n , a dual inhibitor of\n VEGFR<\/jats:styled-content>\n and\n CSF1R<\/jats:styled-content>\n , in patients with recurrent high\u2010grade gliomas.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Eligible patients (aged \u2265\u200918) with histologically or cytologically confirmed recurrent high\u2010grade gliomas were included. Patients were administered different doses of SYHA1813 daily to assess its safety and initial efficacy.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Sixty\u2010four individuals with high\u2010grade gliomas were enrolled. Treatment\u2010related adverse events (TRAEs) were reported in 92.2% of the patients, with 40.6% experiencing grade 3 or higher TRAEs. No grade 5 TRAE was reported. The overall objective response rate (ORR) and disease control rate (DCR) were 18.8% (95% confidence interval [CI], 10.1\u201330.5) and 51.6% (95% CI, 38.7\u201364.3), respectively. With a median follow\u2010up duration of 9.5\u2009months, the median progression\u2010free survival (PFS) was 2.8\u2009months (95% CI, 2.3\u20134.2) with PFS\u20106 of 22.5% (95% CI, 11.8\u201335.4) and the median OS was 15.1\u2009months (95% CI, 10.2\u2013NE) with OS\u201012 of 63.3% (95% CI, 49.3\u201374.4). Among the 38 patients with glioblastoma, the ORR was 18.4% (95% CI, 7.7\u201334.3), with a DCR of 52.6% (95% CI, 35.8\u201369.0). The median PFS and OS were 4.1\u2009months (95% CI, 2.3\u20135.3) and 13.0\u2009months (95% CI, 9.1\u2013NE), respectively. SYHA1813 was detected in cerebrospinal fluid samples and the drug concentration to plasma free drug concentration ratio was 0.30\u20131.27.<\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n SYHA1813 exhibits encouraging anti\u2010tumor activity with a manageable safety profile for the treatment of recurrent high\u2010grade gliomas, especially glioblastoma.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n chictr.org.cn<\/jats:ext-link>\n (ChiCTR2100045380)\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acn3.70166","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T04:55:29Z","timestamp":1755924929000},"page":"2349-2357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["SYHA1813<\/scp>\n , A\n VEGFR<\/scp>\n and\n CSF1R<\/scp>\n Inhibitor, in Patients With Recurrent High\u2010Grade Gliomas: A Multicenter, Open\u2010Label Phase I Study"],"prefix":"10.1002","volume":"12","author":[{"given":"Zhuang","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Neuro\u2010Oncology, Cancer Center, Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology, Cancer Center, Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tangdu Hospital Air Force Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9413-1030","authenticated-orcid":false,"given":"Qianxue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hubei General Hospital Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hubei General Hospital Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Research Center, Huashan Hospital Fudan University Shanghai 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