{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:27:51Z","timestamp":1791912471246,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031160","name":"Cartesian Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031160","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS115426\u201001A1"],"award-info":[{"award-number":["NS115426\u201001A1"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R25NS088248"],"award-info":[{"award-number":["R25NS088248"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R44NS137943"],"award-info":[{"award-number":["R44NS137943"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We report the 12\u2010month follow\u2010up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes\u201008, a BCMA\u2010directed RNA chimeric antigen receptor T\u2010cell (rCAR\u2010T) therapy for refractory generalized myasthenia gravis (MG). These findings provide insight into the potential applicability of BCMA\u2010targeted rCAR\u2010T therapy for antibody\u2010mediated autoimmune diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In the Phase 2a part of the study, Descartes\u201008 was administered at 52.5\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      CAR+ cells\/kg per infusion with varying dosing frequencies as an outpatient treatment and without lymphodepletion chemotherapy. A subset of participants received Descartes\u201008 as six weekly infusions and were followed long term with assessments conducted at 2, 3, 6, 9, and 12\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All seven participants who received six weekly infusions of Descartes\u201008 exhibited clinically meaningful improvement in common MG severity scales (MG Composite, MG Activities of Daily Living, Quantitative MG scores, and Quality of Life 15\u2010revised) at Month 3 without significant toxicity. At Month 9 follow\u2010up, all participants continued to experience marked clinically meaningful improvements. Five out of seven participants maintained the response at Month 12. A third participant experienced a relapse approximately 6\u2009months after completing on\u2010study follow\u2010up. All three participants who experienced loss of clinical effects were retreated. Two had rapid improvement in clinical scores with minimal symptom expression at Week 8, which was maintained through 12\u2009months of retreatment follow\u2010up. The third participant experienced similar improvement in MG severity scores to their initial treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>These data support continued development of Descartes\u201008 in myasthenia gravis and other autoantibody\u2010associated autoimmune disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70167","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T09:35:45Z","timestamp":1756200945000},"page":"2358-2366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Durability of Response to B\u2010Cell Maturation Antigen\u2010Directed\n                    <scp>mRNA<\/scp>\n                    Cell Therapy in Myasthenia Gravis"],"prefix":"10.1002","volume":"12","author":[{"given":"Nizar","family":"Chahin","sequence":"first","affiliation":[{"name":"Department of Neurology Oregon Health and Sciences University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Sahagian","sequence":"additional","affiliation":[{"name":"Neurology Center of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc H.","family":"Feinberg","sequence":"additional","affiliation":[{"name":"SFM Research  Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Andrew","family":"Stewart","sequence":"additional","affiliation":[{"name":"Cartesian Therapeutics  Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Jewell","sequence":"additional","affiliation":[{"name":"Cartesian Therapeutics  Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Kurtoglu","sequence":"additional","affiliation":[{"name":"Cartesian Therapeutics  Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5848-6320","authenticated-orcid":false,"given":"Milo\u0161 D.","family":"Miljkovi\u0107","sequence":"additional","affiliation":[{"name":"Cartesian Therapeutics  Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Neurology University of South Florida  Tampa Florida 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