{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:03:35Z","timestamp":1791299015787,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS098023"],"award-info":[{"award-number":["R01NS098023"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS124882"],"award-info":[{"award-number":["R01NS124882"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus controls and its associations with multi\u2010domain function and disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter cross\u2010sectional study, participants completed a survey covering 71 post\u2010infection symptoms, distinguishing new\u2010onset from worsening symptoms. We defined long COVID using the 2024 NASEM criteria. Logistic regression assessed long COVID odds. Linear and Poisson regression evaluated associations with function and disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>969 pwMSRD (82.5% female, mean age 51.8\u2009years, 63.5% infected) and 1003 controls (79.4% female, mean age 45.2\u2009years, 61.2% infected) were included. PwMSRD had higher odds of long COVID (aOR\u2009=\u20091.6 [1.2\u20132.1]), with a stronger association when restricting to worsening symptoms (aOR\u2009=\u20092.3 [1.7\u20133.1]). Having long COVID was associated with worse physical function, cognition, and depression in both groups. PwMSRD with long COVID experienced greater physical function declines and more depression severity exacerbation than controls, and had faster disability progression compared to those without long COVID.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PwMSRD show\u00a0increased susceptibility to long COVID, primarily driven by worsening symptoms. Long COVID contributes to more functional decline and disability worsening. Recognizing and managing long COVID is essential for pwMSRD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70184","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T11:46:04Z","timestamp":1757072764000},"page":"2446-2459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\n                    <scp>COVID<\/scp>\n                    in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"12","author":[{"given":"Chen","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Translational &amp; Computational Neuroimmunology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"McAlpine","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L. 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