{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T06:37:55Z","timestamp":1765521475247,"version":"3.48.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Soluble interleukin\u20102 receptor (sIL\u20102R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody\u2010associated disease (MOGAD) pathogenesis. However, sIL\u20102R has so far not been evaluated in these conditions. Here, we compared sIL\u20102R levels in serum and cerebrospinal fluid (CSF) of patients with aquaporin\u20104\u2010IgG\u2010seropositive and seronegative (AQP4\u2010IgG+\/\u2212) NMOSD, MOGAD, and noninflammatory neurologic disorders (NINDs), and assessed the prognostic value of sIL\u20102R for future attacks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of real\u2010world data of patients treated at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin was conducted (45 MOGAD, 14 AQP4\u2010IgG+NMOSD, 10 AQP4\u2010IgG\u2212NMOSD, 69 NINDs) between 2010 and 2024. Mean (SD) follow\u2010up time was 40 (35) months. sIL\u20102R differences were assessed by linear mixed models. Cox regression analysis was performed to investigate the predictive value for subsequent attacks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum sIL\u20102R was higher in AQP4\u2010IgG+NMOSD (estimated marginal mean [EMM] 802\u2009IU\/mL) and MOGAD (569\u2009IU\/mL) compared to NINDs (404\u2009IU\/mL). In patients with a first manifestation of MOGAD, but not NMOSD, serum sIL\u20102R (HR\u2009=\u20099.07 [95% CI 1.37\u201360.01]) and CSF sIL\u20102R (HR\u2009=\u20093.27 [95% CI 0.61\u201317.45]) levels were predictive for subsequent attacks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Serum sIL\u20102R is elevated in AQP4\u2010IgG+NMOSD and MOGAD and may be a prognostic biomarker for a relapsing disease course in MOGAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70186","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T12:25:12Z","timestamp":1757075112000},"page":"2460-2469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Soluble Interleukin\u20102 Receptor as a Prognostic Biomarker in\n                    <scp>NMOSD<\/scp>\n                    and\n                    <scp>MOGAD<\/scp>"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0058-2365","authenticated-orcid":false,"given":"Philipp","family":"Klyscz","sequence":"first","affiliation":[{"name":"Experimental and Clinical Research Center, a Cooperation Between Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association and Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Neuroscience Clinical Research Center (NCRC) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1962-6014","authenticated-orcid":false,"given":"Klemens","family":"Ruprecht","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology, Department of Neurology University of Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-1791","authenticated-orcid":false,"given":"Susanna","family":"Asseyer","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a Cooperation Between Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association and Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Neuroscience Clinical Research Center (NCRC) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8392-1942","authenticated-orcid":false,"given":"Hannes Ole","family":"Tiedt","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Meisel","sequence":"additional","affiliation":[{"name":"Labor Berlin Charit\u00e9\u2010Vivantes GmbH  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Bellmann\u2010Strobl","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a Cooperation Between Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association and Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-0070","authenticated-orcid":false,"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a Cooperation Between Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association and Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Neuroscience Clinical Research Center (NCRC) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-121X","authenticated-orcid":false,"given":"Patrick","family":"Schindler","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a Cooperation Between Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association and Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Neuroscience Clinical Research Center (NCRC) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin 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