{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:47:41Z","timestamp":1784684861746,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["B83C22004800006"],"award-info":[{"award-number":["B83C22004800006"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009888","name":"Regione Toscana","doi-asserted-by":"publisher","award":["D19G22000640002"],"award-info":[{"award-number":["D19G22000640002"]}],"id":[{"id":"10.13039\/501100009888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Plasma p\u2010tau181 has proven to be a promising diagnostic and prognostic tool in the earliest phases of Alzheimer's disease (AD). We aimed to evaluate the prognostic role of p\u2010tau181 in predicting conversion to AD dementia and worsening in cognition in mild cognitive impairment (MCI) and subjective cognitive decline (SCD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We consecutively enrolled 163 patients (50 SCD, 70 MCI, and 43\n                      <jats:sc>AD<\/jats:sc>\n                      \u2010demented (AD\u2010d)), who underwent plasma p\u2010tau181 analysis with the Simoa assay. Patients were classified according to the Revised Criteria of the Alzheimer's Association Workgroup as Core1+ or Core1\u2212 (based on amyloid\u2010PET, CSF A\u03b242\/A\u03b240, CSF p\u2010tau181\/A\u03b242).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma p\u2010tau181 levels were significantly influenced by Core1 status (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u20091.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and clinical diagnosis (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u20090.63,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Plasma p\u2010tau181 was highly accurate in discriminating between Core1+ and Core1\u2212 patients (AUC\u2009=\u20090.88 [95% CI 83.00\u201394.00]) with a cut\u2010off value of 2.25\u2009pg\/mL presenting good accuracy (85.90%), specificity (74.58%), and excellent sensitivity (92.78%). Classifying patients according to p\u2010tau181 cut\u2010off, we found that p\u2010tau181+ patients showed an increased risk of converting to AD dementia (HR\u2009=\u200911.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). Moreover, SCD p\u2010tau181+ worsened over time in tasks assessing long\u2010term verbal (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) and spatial memory (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma p\u2010tau181 is not only a good diagnostic marker for AD pathology, but it also plays a role as a predictor of both conversion to AD dementia and of worsening of cognitive performance since the earliest phase of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70190","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T12:11:30Z","timestamp":1757506290000},"page":"2495-2504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasma p\u2010tau181 as a Marker of Conversion to Alzheimer's Disease Dementia and Worsening in Cognitive Functions in Subjective Cognitive Decline and Mild Cognitive Impairment: A Longitudinal Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8711-331X","authenticated-orcid":false,"given":"Giulia","family":"Giacomucci","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assunta","family":"Ingannato","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Crucitti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bagnoli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Marcantelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Padiglioni","sequence":"additional","affiliation":[{"name":"Research and Innovation Centre for Dementia\u2010CRIDEM, AOU Careggi  Florence Italy"},{"name":"Regional Referral Centre for Relational Criticalities \u2013 Tuscany Region  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Moschini","sequence":"additional","affiliation":[{"name":"Research and Innovation Centre for Dementia\u2010CRIDEM, AOU Careggi  Florence Italy"},{"name":"SOD Neurologia, Dipartimento Neuromuscolo\u2010Scheletrico e degli Organi di Senso, AOU Careggi  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Morinelli","sequence":"additional","affiliation":[{"name":"Research and Innovation Centre for Dementia\u2010CRIDEM, AOU Careggi  Florence Italy"},{"name":"SOD Neurologia, Dipartimento Neuromuscolo\u2010Scheletrico e degli Organi di Senso, AOU Careggi  Florence 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