{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:28:49Z","timestamp":1781720929437,"version":"3.54.5"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH236"],"award-info":[{"award-number":["ZR2021MH236"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Previous studies examining post\u2010stroke aphasia (PSA) patients via resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) have predominantly focused on static functional connectivity. In contrast, the current investigation aims to elucidate the alterations in dynamic functional network connectivity (dFNC) among PSA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We recruited 40 PSA patients and 41 age\u2010, gender\u2010, and education\u2010matched normal controls (NCs). The participants underwent rs\u2010fMRI and the Western Aphasia Battery (WAB) test. Independent component analysis (ICA) was used to identify resting\u2010state networks (RSNs), and dFNC was constructed using a sliding window technique followed by\n                      <jats:italic>k<\/jats:italic>\n                      \u2010means clustering to classify distinct dynamic network states. We compared the dFNC differences between the PSA and NC groups and examined their relationships with clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The dynamic analysis identified 4 distinct dFNC states: state 1 (modular network state), state 2 (pan\u2010network hyperconnectivity state), state 3 (intra\u2010network coordinated state), and state 4 (sparse connectivity state). Notable group differences were observed: compared with NCs, the PSA group demonstrated significantly reduced connectivity within the language network (LN) and increased connectivity between the cerebellar network (CN) and the default mode network (DMN) in state 3; significantly reduced connectivity changes within the LN and between the LN and executive control network (ECN) \/ CN were noted in state 4. Additionally, fraction time and mean dwell time in the modular network state were positively correlated with the WAB score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Alteration in dFNC could serve as a sensitive biomarker toward language impairment in PSA patients, with implications for diagnostic assessment and therapeutic intervention planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70194","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T12:29:15Z","timestamp":1758889755000},"page":"97-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Altered Dynamic Functional Network Connectivity in Post\u2010Stroke Aphasia"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6636-3021","authenticated-orcid":false,"given":"Guihua","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiology Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2970-5068","authenticated-orcid":false,"given":"Junyu","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Radiology Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Xin","sequence":"additional","affiliation":[{"name":"MR Research Collaboration Siemens Healthineers Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4488-2135","authenticated-orcid":false,"given":"Dawei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University  Jinan China"},{"name":"Shandong Key Laboratory for Magnetic Field\u2010Free Medicine and Functional Imaging, Institute of Magnetic Field\u2010Free Medicine and Functional Imaging Shandong University  Jinan China"},{"name":"National Innovation Platform for Industry\u2010Education Integration in Medicine\u2010Engineering Interdisciplinary Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-4543(21)00853-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194143"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2025.04.015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000221815.64093.8c"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.1.11"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103190"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2014.10.2.75"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac129"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88022-z"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132388"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1906144117"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00167"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006738"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2016.0419"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51217"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.165"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa023"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000259632.04324.6c"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf036"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.07.019"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs352"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13387"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-023-01148-2"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106493"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2023.148406"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25366"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.52074"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.771034"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102507"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa101"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshd.4503.308"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.52238"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10171"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-016-9299-4"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1193-2"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20359"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1995.7.6.1129"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.03.027"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1024"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23430"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.08.072"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137097"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz192"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.07.003"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.08.063"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxm045"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0030-1299.2005.13727.x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-024-00802-4"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54277"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2023.114344"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22448"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2012.11.004"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12358-5"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1044\/2020_AJSLP-19-00150"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.062"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1006\/brln.2001.2569"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-022-01482-5"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.01.014"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018985108"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169015"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T14:18:08Z","timestamp":1768054688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.70194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/acn3.70194"],"URL":"https:\/\/doi.org\/10.1002\/acn3.70194","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"2025-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}