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<\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A preliminary survey questionnaire was sent to 1574 selected departments (neurology and pediatrics\/pediatric neurology) to explore the numbers of AM and plexin D1\u2010IgG\u2010positive patients between 2018 and 2022. A secondary survey collected detailed patient data via a questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the preliminary survey, 987 (62.7%) institutions responded, reporting 87\u2009AM patients (49 women) and 11 plexin D1\u2010IgG\u2010positive non\u2010AM patients (8 women). The secondary survey collected 71\u2009AM (plexin D1\u2010IgG\u2010positive: 6\/31) and 11 plexin D1\u2010IgG\u2010positive non\u2010AM patients (83.7% recovery rate). In AM, paresthesia\/dysesthesia was most frequently experienced (&gt;\u200990%), followed by pain (&gt;\u200970%). The underlying diseases in 17 plexin D1\u2010IgG\u2010positive patients, all of whom had neuropathic pain, were AM and small fiber neuropathy in 6 each, neuromyelitis optica spectrum disorder with aquaporin\u20104\u2010IgG in 2, and painful trigeminal neuropathy, erythromelalgia, and multiple sclerosis in 1 each. When 14 plexin D1\u2010IgG\u2010positive patients (excluding 3 patients with established demyelinating diseases) were compared with 25 plexin D1\u2010IgG\u2010negative AM patients, onset \u2265\u200950\u2009years old, pain at onset, and allodynia\/erythromelalgia\/facial pain during the entire disease course were significantly more common in the plexin D1\u2010IgG\u2010positive group. Conversely, atopic disorders and hyperIgEemia were associated with plexin D1\u2010IgG\u2010negative AM but not plexin D1\u2010IgG\u2010positive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Both AM and plexin D1\u2010IgG\u2010positive patients present long\u2010standing neuropathic pain, whereas plexin D1\u2010IgG is particularly associated with aged\u2010onset neuropathic pain, allodynia, erythromelalgia, and facial pain, but not atopy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70232","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:17:13Z","timestamp":1764051433000},"page":"593-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nationwide Survey of Atopic Myelitis and Plexin\n                    <scp>D1<\/scp>\n             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