{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:58:48Z","timestamp":1778612328064,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006392","name":"AIDS Clinical Trials Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low\u2010field MRI (LF\u2010MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH. We sought to evaluate the feasibility of LF\u2010MRI and apply a machine learning (ML) segmentation algorithm to examine atrophy and white matter hyperintensities (WMH) in PWH compared to people without HIV (PWoH) of similar age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Individuals with a confirmed diagnosis of HIV on antiretroviral therapy underwent LF\u2010MRI (64 mT) acquisition in the outpatient neurology clinic. PWoH with &gt;\u20091 vascular comorbidity (VC cohort,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925) or with mild cognitive impairment (MCI cohort,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) due to Alzheimer's disease served as comparators. LF\u2010MRI brain region segmentations were derived using the ML algorithm WMH\u2010SynthSeg in FreeSurfer. Brain regions corrected for intracranial volume were compared between cohorts after adjusting for age and sex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty virally suppressed PWH were included. LF\u2010MRI derived brain volumes from PWH demonstrated a reduction in volume of the caudate relative to PWoH with VC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Volume of the putamen and white matter was reduced in PWH compared to VC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Hippocampal volume was comparable between PWH and PWoH (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2265\u20090.05), while volume of the amygdala was reduced in those with MCI alone (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). No differences in WMH were seen between these cohorts (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>LF\u2010MRI is feasible in an outpatient setting, and ML algorithms enable detection of regional atrophy and WMH in PWH. LF\u2010MRI may enable more frequent monitoring and earlier detection of atrophy in at\u2010risk populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70237","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T11:16:38Z","timestamp":1762427798000},"page":"537-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Portable Low\u2010Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-3898","authenticated-orcid":false,"given":"Annabel","family":"Sorby\u2010Adams","sequence":"first","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Center for Genomic Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6288-7619","authenticated-orcid":false,"given":"Malachi","family":"Keo","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Center for Genomic Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daire","family":"Daly","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Ahern","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimon","family":"Zachary","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Robbins","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh T.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-0404","authenticated-orcid":false,"given":"Bragi","family":"Sveinsson","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"de Havenon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Brain &amp; Mind Health Yale New Haven Hospital and Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-5473","authenticated-orcid":false,"given":"Kevin N.","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Brain &amp; Mind Health Yale New Haven Hospital and Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Rapalino","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Eugenio","family":"Iglesias Gonzales","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Centre for Medical Image Computing University College London  London UK"},{"name":"Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-8530","authenticated-orcid":false,"given":"W. Taylor","family":"Kimberly","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Center for Genomic Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibani S.","family":"Mukerji","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Vaccine and Immunotherapy Center Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"(CDC) CfDCaP \u201cHIV Surveillance Report: Diagnoses Deaths and Prevalence of HIV in the United States and 6 Territories and Freely Associated States 2022 \u201d(2024) https:\/\/stacks.cdc.gov\/view\/cdc\/156509."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(24)00248-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003862"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1391"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13446"},{"key":"e_1_2_9_7_1","unstructured":"(NIH) NIoH \u201cHIV and the Older Person \u201d(2024) https:\/\/clinicalinfo.hiv.gov\/en\/guidelines\/hiv\u2010clinical\u2010guidelines\u2010adult\u2010and\u2010adolescent\u2010arv\/special\u2010populations\u2010hiv\u2010and\u2010older."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae479"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104488"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.10.005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201186"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/11586390-000000000-00000"},{"key":"e_1_2_9_13_1","unstructured":"WHO \u201cHIV Statistics Globally and by WHO Region 2024 \u201d(2024) https:\/\/cdn.who.int\/media\/docs\/default\u2010source\/hq\u2010hiv\u2010hepatitis\u2010and\u2010stis\u2010library\/j0482\u2010who\u2010ias\u2010hiv\u2010statistics_aw\u20101_final_ys.pdf?sfvrsn=61d39578_3."},{"issue":"4","key":"e_1_2_9_14_1","article-title":"Impact of Magnetic Resonance Imaging on Healthcare in Low\u2010 and Middle\u2010Income Countries","volume":"15","author":"Hilabi B. 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