{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:17:51Z","timestamp":1790036271165,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2023KY905"],"award-info":[{"award-number":["2023KY905"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune\u2010inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers' predictive efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study of ischemic stroke patients, C\u2010reactive protein\u2010albumin\u2010lymphocyte (CALLY), Systemic Immune\u2010Inflammation Index (SII), and Systemic Inflammation Response Index (SIRI) were assessed. Immune\u2010inflammation changes were measured between baseline and a second survey. The primary outcome was death or major disability (modified Rankin Scale score\u2009\u2265\u20093) after stroke onset. Prognostic performance for poor outcomes was evaluated at baseline. The association was calculated by Cox proportional hazard models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Elevated baseline CALLY correlated with reduced poor outcome risk (OR 0.33, 95% CI 0.20\u20130.53), while higher SII and SIRI indicated increased risk (SII OR 2.54, 95% CI 1.61\u20134.06; SIRI OR 2.37, 95% CI 1.47\u20133.87). Adding these markers to conventional risk factors significantly improved prediction, with CALLY showing the greatest enhancement (\n                      <jats:italic>C<\/jats:italic>\n                      \u2010statistic 0.882 vs. 0.862;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004; NRI\u2009=\u200929.68%; IDI\u2009=\u20090.39%). Compared to stable mild status, progression to severe status increased poor outcome risk, while recovery to mild status reduced risk (CALLY OR 14.2, 95% CI 2.31\u201364.27; SII OR 1.27, 95% CI 1.01\u20137.10; SIRI OR 4.10, 95% CI 1.61\u201310.71). High inflammatory indices and significant changes predicted poor outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CALLY demonstrated superior predictive ability for ischemic stroke outcomes versus SII\/SIRI. Both baseline levels and dynamic changes in immune\u2010inflammation status significantly correlated with prognosis, suggesting these biomarkers could valuably predict outcomes and guide intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70252","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:38:10Z","timestamp":1764052690000},"page":"767-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Changes in Immune\u2010Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort"],"prefix":"10.1002","volume":"13","author":[{"given":"Songfang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou  China"},{"name":"Wenzhou\u00a0Key Laboratory of Neurogenetics  Wenzhou 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