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People with epilepsy diagnosed with cognitive impairment were consecutively invited. Those who agreed were followed up for at least 24\u2009weeks. Participants were required to be adherent to their antiseizure medication regimens, which had remained unchanged for at least 24\u2009weeks before recruitment. Participants were prescribed memantine and categorized according to their treatment decisions (memantine group vs. non\u2010memantine group). Primary outcome measures were the occurrence of new\u2010onset bilateral tonic\u2013clonic seizure, new\u2010onset status epilepticus, and increased seizure frequency (\u2265\u200925%). The incidence of other adverse events (AEs) and 24\u2010week retention rate were secondary outcome measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred and eleven participants were enrolled (median age, 63; male, 65%). Among them, one hundred and one (48%) started memantine. Baseline seizure characteristics were comparable between the two groups. During follow\u2010up, no new\u2010onset bilateral tonic\u2013clonic seizure was recorded; there was one status epilepticus in the non\u2010memantine group. Increased seizure frequency was reported by 12 (6%) participants (memantine vs. non\u2010memantine, seven vs. five). Other AEs in the memantine group included headache (7%), dizziness (5%), fatigue (4%), drowsiness (2%), and anorexia (2%). The 24\u2010week retention rate was 91%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Adjunctive memantine was well tolerated in people with epilepsy regarding seizure control and other AEs. Previous warnings might have been disproportionate. Large\u2010scale, randomized trials are required to confirm this and further elucidate its efficacy profiles in epilepsy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70262","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:37:33Z","timestamp":1764074253000},"page":"780-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Will Memantine Exacerbate Seizures in People With Epilepsy? 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