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While corticosteroids, intravenous immunoglobulin, and plasmapheresis are effective first\u2010line immunotherapies, a subset of patients remains treatment\u2010refractory. Daratumumab, an anti\u2010CD38 monoclonal antibody approved for multiple myeloma, demonstrates immunomodulatory effects suggesting utility in refractory neuroimmune disorders. However, evidence for its efficacy in CIDP remains limited. We report a case study of treatment\u2010refractory CIDP successfully managed with daratumumab, including 1 year follow\u2010up data.<\/jats:p>","DOI":"10.1002\/acn3.70265","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T12:46:46Z","timestamp":1764247606000},"page":"622-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Daratumumab Treatment for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (\n                    <scp>CIDP<\/scp>\n                    ): A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4585-6315","authenticated-orcid":false,"given":"Xueyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Huanhu Hospital Affiliated to Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6778-7889","authenticated-orcid":false,"given":"Yu\u2010Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"issue":"8","key":"e_1_2_8_2_1","article-title":"Plasma Exchange for Chronic Inflammatory Demyelinating Polyradiculoneuropathy","volume":"2015","author":"Mehndiratta M. 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