{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:04:26Z","timestamp":1787061866457,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["2RF1NS036695\u201020"],"award-info":[{"award-number":["2RF1NS036695\u201020"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019823","name":"University of Maryland, Baltimore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005902","name":"Institute for Clinical and Translational Research, University of Wisconsin, Madison","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005902","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi\u2010 and contra\u2010lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post\u2010ICH ambulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with spontaneous supratentorial ICH were recruited from 8 US sites between 2017 and 2024. For each patient, fractional anisotropy (FA) asymmetry index (AI) was computed for the whole CST and on a subset of fibers restricted to the cerebral peduncle (CP). Clinical and radiographic features were collected. The primary outcome was Barthel Index Mobility Score (BIMS) at 3\u2009months (dichotomized outcome [DO]: BIMS 15\u2009=\u2009good [independent ambulation]; BIMS &lt;\u200915\u2009=\u2009poor [non\u2010independent ambulation]; ordinal outcome [OO]: BIMS 0, 5, 10, 15). Two imputation\u2010based multiple logistic regression analyses accounted for whether ICH prevented tracking of CSTs. Odds ratios (ORs) were reported for a change of 0.1 and 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 3\u2009months, 124 patients were eligible for inclusion. In addition to known clinical variables, CST and CP FA AI were associated with poor BIMS (OR 2.97, CI 1.12\u20137.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029; OR 3.80, CI 1.63\u20138.84,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). In Model 1, unresolved FA (FA zero) was not correlated with lower BIMS (DO: OR 3.25, CI 0.62\u201317.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.163; ordinal outcomes: OR 2.02, CI 0.48\u20138.55,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.341). In Model 2, the combination of CST FA AI and FA zero correlated with lower BIMS (DO: joint\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value =0.041; OO:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030). CP FA asymmetry was associated with lower BIMS (DO: OR 3.96, CI 1.25\u201312.55,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019; OO: OR 3.39, CI 1.24\u20139.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DTI\u2010assessed CST integrity may be an additional tool physicians can utilize to guide post\u2010ICH ambulatory expectations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70266","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:12:42Z","timestamp":1765595562000},"page":"948-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3515-4005","authenticated-orcid":false,"given":"Yasmin N.","family":"Aziz","sequence":"first","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl D.","family":"Langefeld","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Center for Precision Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Comeau","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Center for Precision Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda C.","family":"Marion","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Center for Precision Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler P.","family":"Behymer","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee A.","family":"Gilkerson","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmini","family":"Sekar","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Division of Radiology, Imaging Research Center Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Radiology, College of Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Khandwala","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brady J.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Maloney","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achala","family":"Vagal","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierce","family":"Boyne","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Exercise and Nutrition Sciences University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Dunning","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Exercise and Nutrition Sciences University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Flaherty","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Kittner","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Mehndiratta","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan Y.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Duke University  Durham North Carolina USA"},{"name":"Department of Neurology Duke University  Durham North Carolina 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