{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T09:08:52Z","timestamp":1779008932942,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AG068802\u201001"],"award-info":[{"award-number":["R21 AG068802\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1 AG079324"],"award-info":[{"award-number":["RF1 AG079324"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine neurophysiological underpinnings of improvement, and whether connectivity profiles may be useful in evaluating and predicting longer\u2010term cognitive outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients hospitalized with a minor ischemic stroke (NIH Stroke Scale &lt;\u200910) were neurologically evaluated approximately 1\u2009month following discharge. A battery of neuropsychological tests was administered to assess performance across multiple cognitive domains. Functional connectivity was evaluated using resting state magnetoencephalography (MEG). Repeat evaluations were performed 3\u20136\u2009months later. The Network Localized Granger Causality framework was used to estimate functional connectivity at each visit. Relationships between functional connectivity and cognitive performance at each visit were assessed using cluster\u2010based permutation tests and mixed effects modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010nine patients had available data for both follow\u2010up visits. The average age was 62.4\u2009years; 57% were female; 39% were Black. Mixed effects models indicated significant increases in contralesional frontoparietal beta\u2010band connectivity across visits that corresponded to improved behavioral performance. Early reliance on the contralesional hemisphere was associated with better scores at visit 1, and continued reliance on areas within the ipsilesional hemisphere was associated with poorer performance at visit 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Specific connectivity profiles are associated with better acute and longer\u2010term cognitive performance and may indicate greater potential for recovery. Further studies are needed to determine if patterns are modifiable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70271","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T14:58:28Z","timestamp":1765033108000},"page":"888-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Connectivity Linked to Cognitive Recovery After Minor Stroke"],"prefix":"10.1002","volume":"13","author":[{"given":"Vrishab","family":"Commuri","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering The University of Maryland  College Park Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5852-3124","authenticated-orcid":false,"given":"Isabella","family":"Dallasta","sequence":"additional","affiliation":[{"name":"Department of Neurology The Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciaran","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Cognitive Science The University of Maryland  College Park Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Girgenti","sequence":"additional","affiliation":[{"name":"Department of Neurology The Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Gould","sequence":"additional","affiliation":[{"name":"Department of Psychology The Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael H.","family":"Llinas","sequence":"additional","affiliation":[{"name":"Department of Neurology The Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-0698","authenticated-orcid":false,"given":"Jonathan Z.","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering The University of Maryland  College Park Maryland USA"},{"name":"Department of Biology The University of Maryland  College Park Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-5074","authenticated-orcid":false,"given":"Elisabeth Breese","family":"Marsh","sequence":"additional","affiliation":[{"name":"Department of Neurology The Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(19)30034\u20101"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(17)30299\u20105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1503780"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017320"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1414792"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12424"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2017.12.020"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad149"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac012"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/2632-072X\/ac3ddd"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2571"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941874415619964"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/003693305700200504"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521288"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1534480"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00267"},{"key":"e_1_2_10_19_1","unstructured":"C.Brodbeck P.Das J. 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