{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:35:15Z","timestamp":1773041715001,"version":"3.50.1"},"reference-count":4,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This is a case of a 28\u2010year\u2010old man who presented with a 6\u2010month history of gradually progressive proximal leg weakness and pain that worsened on exercise and was relieved by rest. He had no symptoms in his upper limbs. Apart from intermittent mild ptosis and diplopia, he had no other cranial nerve symptoms. Sensation, bladder, and bowel function were normal. His examination revealed fatigable ptosis and diplopia with a positive ice\u2010pack test. His motor examination showed mild fatigable hip flexion weakness and hyporeflexia that recovered on brief exercise. Electrophysiologic studies revealed small motor nerve amplitudes that improved with brief exercise, and a significant decrement on slow repetitive nerve stimulation. He had a positive anti\u2010VGCC antibody. The clinical, electrophysiological, and antibody findings supported a diagnosis of Lambert Eaton Myasthenic syndrome (LEMS). LEMS commonly presents as a paraneoplastic syndrome associated with small cell lung cancer in older male smokers. However, some forms are primarily autoimmune, as was the case in our patient.<\/jats:p>","DOI":"10.1002\/acn3.70290","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T07:14:46Z","timestamp":1767078886000},"page":"641-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Case of a 28\u2010Year\u2010Old Man With Gradually Progressive Proximal Leg Weakness"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3745-8982","authenticated-orcid":false,"given":"Melody T.","family":"Asukile","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, School of Medicine University of Zambia  Lusaka Zambia"},{"name":"Neurological Association of Zambia  Lusaka Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musambo","family":"Kapapa","sequence":"additional","affiliation":[{"name":"Neurological Association of Zambia  Lusaka Zambia"},{"name":"Department of Physiotherapy, School of Health Sciences University of Zambia  Lusaka Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emelda","family":"Mwingila","sequence":"additional","affiliation":[{"name":"Neurological Association of Zambia  Lusaka Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Kvalsund","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine University of Zambia  Lusaka Zambia"},{"name":"Neurological Association of Zambia  Lusaka Zambia"},{"name":"School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"\u201cLambert\u2010Eaton Myasthenic Syndrome: Clinical Features and Diagnosis\u2014UpToDate \u201d(2025) https:\/\/www.uptodate.com\/contents\/lambert\u2010eaton\u2010myasthenic\u2010syndrome\u2010clinical\u2010features\u2010and\u2010diagnosis."},{"key":"e_1_2_7_3_1","unstructured":"\u201cLambert\u2010Eaton Myasthenic Syndrome: Treatment and Prognosis\u2014UpToDate \u201d(2025) https:\/\/www.uptodate.com\/contents\/lambert\u2010eaton\u2010myasthenic\u2010syndrome\u2010treatment\u2010and\u2010prognosis."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(02)00054-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70245-9"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.70290","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:45:05Z","timestamp":1773038705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.70290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":4,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/acn3.70290"],"URL":"https:\/\/doi.org\/10.1002\/acn3.70290","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"2025-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}