{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:07:12Z","timestamp":1792260432829,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R44NS117214"],"award-info":[{"award-number":["NIH R44NS117214"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the test performance of cutaneous phosphorylated alpha\u2010synuclein (P\u2010SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is the first subgroup analysis of the Synuclein\u2010One study, a prospective, blinded study evaluating P\u2010SYN detection from skin biopsies in 218 subjects with a referral diagnosis of control (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009151) and DLB (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200967). All subjects completed detailed examinations, questionnaires, and had skin biopsies for detection of P\u2010SYN. DLB patients were included if meeting the 4th DLB consensus probable criteria. Control subjects, aged 40\u201399, had no history, examination findings, or symptoms suggestive of a synucleinopathy or neurodegenerative disease. An expert review panel, blinded to pathological data, determined the final diagnosis. Controls with reduced MoCA (MoCA &lt;\u200926,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200926) at screening were analyzed separately.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After expert panel review, only 50\/67 patients met consensus criteria for DLB, 26\/151 controls had a reduced MoCA, and 120\/151 controls had a normal MoCA. The proportions of subjects with cutaneous P\u2010SYN detected by skin biopsy were 96.0% (48 of 50) of the DLB group, 31% (8 of 26) of the controls with reduced MoCA, and 3.3% (4 of 120) of the controls with normal MoCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>In this prospective, blinded, cross\u2010sectional study, a high proportion of subjects meeting clinical consensus criteria for DLB had P\u2010SYN detected in skin biopsies. Almost 1\/3 of subjects with reduced MoCA testing also had P\u2010SYN detected. These results support a role for skin biopsy detection of P\u2010SYN in patients with DLB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>NCT04700722<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70291","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T04:52:18Z","timestamp":1766724738000},"page":"1041-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cutaneous Phosphorylated Alpha\u2010Synuclein in Lewy Body Dementia"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0087-5336","authenticated-orcid":false,"given":"Christopher H.","family":"Gibbons","sequence":"first","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Levine","sequence":"additional","affiliation":[{"name":"Honorhealth Neurology  Scottsdale Arizona USA"},{"name":"CND Life Sciences  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey","family":"Bellaire","sequence":"additional","affiliation":[{"name":"CND Life Sciences  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinky","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Booth Gardner Parkinson's Center, Evergreen Health  Kirkland Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina M.","family":"Aldridge","sequence":"additional","affiliation":[{"name":"Department of Neurology Carver College of Medicine, University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Barboi","sequence":"additional","affiliation":[{"name":"Department of Neurology Northshore University Health System  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9853-4902","authenticated-orcid":false,"given":"Daniel","family":"Claassen","sequence":"additional","affiliation":[{"name":"Department of Neurology Vanderbilt  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgilio G. 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