{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:00:40Z","timestamp":1790625640056,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018748","name":"Argenx","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["553539684"],"award-info":[{"award-number":["553539684"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100024149","name":"UCB Pharma Germany","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024149","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life\u2010threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients. This study evaluated whether frequently assessed clinical outcomes via MyaLink can capture symptom variability between clinical visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized, controlled, 12\u2010week study, 45 MG patients received either standard care (control,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200915) or standard care with additional telemedical treatment (intervention,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200930) including assessment of patient\u2010reported outcome measures, sensor\u2010based data, and patient\u2010physician messaging via a mobile application. Physicians performed telemedical check\u2010ups (TCUs) via a web\u2010based platform, adjusting treatment as needed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the intervention group, variability in clinical scores and sensor\u2010derived data was observed, particularly among those who experienced MG\u2010related hospitalizations or exacerbations (H&amp;E subgroup). This subgroup showed larger MG\u2010ADL score fluctuations (mean range: 5.8 vs. 2.6 points), sent more messages, had more steroid dose adjustments (40% vs. 0%), and more frequent TCU interventions (93.3% vs. 60%) than the Non\u2010H&amp;E subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Telemedical platforms in MG might detect early signs of worsening. High\u2010risk patients (H&amp;E subgroup) require increased medical support, which can be effectively addressed through MyaLink.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The study was registered under the German clinical trial registry (DRKS00029907)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70293","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T04:30:22Z","timestamp":1766377822000},"page":"1106-1117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1514-8385","authenticated-orcid":false,"given":"Maike","family":"Stein","sequence":"first","affiliation":[{"name":"Department of 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