{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:11:30Z","timestamp":1783930290179,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>SOX1 antibody\u2010positive paraneoplastic neurological syndromes (PNS) exhibit significant population\u2010specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert\u2010Eaton myasthenic syndrome (65%\u201380%), comprehensive clinical characterization and treatment response data in Asian populations remain critically limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a single\u2010center retrospective case series analyzing 13 consecutive patients with SOX1 antibody\u2010positive PNS treated at Guangdong Sanjiu Brain Hospital from January 2019 to December 2024. SOX1 antibodies were confirmed using commercial immunoblot assay. Primary endpoints included treatment response (\u2265\u20091\u2010point improvement on modified Rankin Scale [mRS]) and functional recovery (mRS \u2264\u20092). Statistical analyses employed Fisher's exact tests and Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 13 patients (median age 61\u2009years [IQR 56\u201367], 53.8% female), neuropsychiatric presentations predominated, including seizures (46.2%) and psychiatric symptoms (30.8%), with combined neuropsychiatric manifestations occurring in 53.8% of patients. Co\u2010existing neuronal antibodies were identified in 15.4% of cases (GABAB receptor, LGI1). Malignancy was confirmed in 30.8% of patients. Immunotherapy recipients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) demonstrated significantly superior functional outcomes compared to non\u2010treated patients: median 3\u2010month mRS 0 (IQR 0\u20130) versus 3 (IQR 3\u20133),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03. Treatment response rates were 85.7% versus 33.3% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.103).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Chinese patients with SOX1 antibody\u2010positive PNS demonstrate a neuropsychiatric\u2010predominant phenotype (53.8%), contrasting markedly with Western cohorts. Early immunotherapy administration was associated with superior functional outcomes (median 3\u2010month mRS: 0 vs. 3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). These findings support comprehensive neuronal antibody profiling and early immunotherapy consideration in patients presenting with neuropsychiatric manifestations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70313","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T04:40:57Z","timestamp":1769229657000},"page":"1379-1387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Spectrum and Outcomes of\n                    <scp>SOX1<\/scp>\n                    Antibody\u2010Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4801-0576","authenticated-orcid":false,"given":"Jin\u2010Long","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Neurology Guangdong Sanjiu Brain Hospital  Guangzhou Guangdong 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