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We used the translocator protein radioligand [\n                    <jats:sup>18<\/jats:sup>\n                    F]DPA\u2010714 and PET to evaluate brain microglial activation. [\n                    <jats:sup>18<\/jats:sup>\n                    F]DPA\u2010714 PET brain images of 11 patients with GAD65 antibody\u2010associated epilepsy and seven controls were analyzed. Patients with acute symptomatic seizures presented higher [\n                    <jats:sup>18<\/jats:sup>\n                    F]DPA\u2010714 SUVR in the hippocampus than did controls and patients with chronic temporal lobe epilepsy. Our findings highlight that [\n                    <jats:sup>18<\/jats:sup>\n                    F]DPA\u2010714 PET\/MRI represents a useful tool to assess neuroinflammation in patients with GAD65 antibody\u2010associated epilepsy.\n                  <\/jats:p>","DOI":"10.1002\/acn3.70324","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:10:46Z","timestamp":1769148646000},"page":"1066-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuroinflammation in\n                    <scp>GAD65<\/scp>\n                    Antibody\u2010Associated Epilepsy Measured Using [\n                    <scp>\n                      <sup>18<\/sup>\n                      F\n                    <\/scp>\n                    ]\n                    <scp>DPA<\/scp>\n                    \u2010714\n                    <scp>PET<\/scp>\n                    \/\n                    <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"13","author":[{"given":"Jingjing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of 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