{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:09:02Z","timestamp":1790780942029,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100028950","name":"BRAIN Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100028950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1176426"],"award-info":[{"award-number":["APP1176426"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GTN1158384"],"award-info":[{"award-number":["GTN1158384"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GTN2009264"],"award-info":[{"award-number":["GTN2009264"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100025520","name":"Medical Research Future Fund","doi-asserted-by":"publisher","award":["MRF1200254"],"award-info":[{"award-number":["MRF1200254"]}],"id":[{"id":"10.13039\/501100025520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010PI\u20102620 tau\u2010PET, clinical, and cognitive outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010four PSP patients and 11 age\u2010 and sex\u2010matched control subjects underwent Cerebrospinal fluid (CSF) and plasma assays of neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total tau (t\u2010tau) using SIMOA. Ratios (NfL\/t\u2010tau, GFAP\/t\u2010tau, GFAP\/NfL) were calculated. Tau burden was quantified using PI\u20102620 distribution volume ratio (DVR). Group comparisons and associations with tau\u2010PET, MRI, and cognition were tested using Wilcoxon tests, ROC analyses, and age\u2010 and sex\u2010adjusted linear models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PSP patients showed elevated NfL, GFAP levels, and higher NfL\/t\u2010tau and GFAP\/t\u2010tau ratios in CSF and plasma. CSF NfL\/t\u2010tau best discriminated PSP from control subjects (AUC\u2009=\u20090.99, 95% CI [0.97\u20131.00]; optimal cut\u2010off: &gt;\u200910), followed by CSF GFAP\/t\u2010tau (AUC\u2009=\u20090.89, 95% CI [0.76\u20131.00]; &gt;\u2009104) and plasma NfL\/t\u2010tau (AUC\u2009=\u20090.80, 95% CI [0.63\u20130.96]; 5.1). Plasma NfL\/t\u2010tau correlated with tau\u2010PET DVR in the putamen (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.63; 95% CI [0.15\u20131.11];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and pallidum (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.54, 95% CI [0.07\u20131.02];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and predicted disease severity (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.61, 95% CI [0.19, 1.04];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and processing speed (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.66, 95% CI [0.22, 1.10];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), explaining 35% and 33% of variance, respectively. Frontal MRI volume modestly improved prediction of processing speed (\u0394\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      adj\u2009=\u20090.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), whereas tau\u2010PET did not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Plasma NfL\/t\u2010tau correlates with regional tau, disease severity, and cognition. Fluid biomarkers, complemented by PET and MRI, may support multimodal PSP diagnosis, monitoring, and trial stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Australian New Zealand Clinical Trials Registry: ACTRN12620001254987<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70327","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T04:46:11Z","timestamp":1769661971000},"page":"1422-1432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1307-6747","authenticated-orcid":false,"given":"Roxane","family":"Dilcher","sequence":"first","affiliation":[{"name":"Department of Neurosciences School of Translational Medicine, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.","family":"Malpas","sequence":"additional","affiliation":[{"name":"Department of Neurosciences School of Translational Medicine, Monash University  Melbourne Victoria Australia"},{"name":"Department of Medicine Royal Melbourne Hospital, The University of Melbourne  Melbourne Victoria Australia"},{"name":"Melbourne School of Psychological Sciences The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-3179","authenticated-orcid":false,"given":"Stuart J.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Neurosciences School of Translational Medicine, Monash University  Melbourne Victoria Australia"},{"name":"Department of Neurology Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Neurosciences School of Translational Medicine, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Despott","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Bertram","sequence":"additional","affiliation":[{"name":"Department of Neurosciences School of Translational Medicine, Monash University  Melbourne Victoria Australia"},{"name":"Department of Neurology Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-8485","authenticated-orcid":false,"given":"Matthew P.","family":"Pase","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences, Turner Institute for Brain and Mental Health Monash University  Clayton Victoria Australia"},{"name":"Harvard T.H. 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