{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:47Z","timestamp":1786988147375,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01NS100811"],"award-info":[{"award-number":["5R01NS100811"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B\u2010PwMS) experience a more severe disease course than non\u2010Hispanic White people with MS (NHW\u2010PwMS). Here we investigated structural and functional connectivity as well as structure\u2013function decoupling in the sensorimotor and default mode networks (SMN and DMN, respectively), which play a key role in determining physical and cognitive disability in people with MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 176 participants (50 B\u2010PwMS, 50 NHW\u2010PwMS, 41 Black healthy controls (B\u2010HCs), and 35 NHW\u2010HCs) underwent 3T\u2010MRI with T1, resting\u2010state functional, &amp; diffusion imaging, and clinical assessment with Expanded\u2010Disability\u2010Status\u2010Scale (EDSS) &amp; Symbol\u2010Digit\u2010Modalities\u2010Test (SDMT). T1\u2010weighted images were lesion\u2010filled and segmented to obtain cortical, subcortical, and cerebellar structures. Diffusion and functional MRI datasets were preprocessed, and structural and functional connectivity were extracted between regions defined by the AAL3 atlas. Global and local network measures were extracted for both structural and functional connectivity, and structure\u2013function decoupling was quantified by calculating the correlation between the strengths of the two networks, considering only edges with non\u2010zero structural connectivity. Network measures were compared between subgroups, accounting for the impact of demographics and social determinants of health, with correction for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Despite similar disease duration, treatment exposure, lesion load and brain volumes, B\u2010PwMS exhibited higher EDSS and lower SDMT scores compared to NHW\u2010PwMS, which were influenced by total income and body mass index. In both B\u2010 and NHW\u2010PwMS, structural global efficiency and streamline density were lower in the SMN and DMN compared to their respective HCs. Structural characteristic path length in SMN was significantly higher in B\u2010PwMS versus B\u2010HCs, whereas no significant differences were observed in NHW groups. Extensive local rearrangements of structural and functional hubs were observed in the SMN and DMN of B\u2010PwMS compared to B\u2010HCs and NHW\u2010PwMS. B\u2010PwMS showed greater structure\u2013function decoupling in the SMN as compared to the other groups. There was a trend towards a higher decoupling in the DMN with lower SDMT scores (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u2009\u22120.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05), and higher decoupling in the SMN with higher EDSS scores (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Despite similar brain volumes and lesion load, B\u2010PwMS showed a greater rearrangement of brain structural and functional connectivity within the SMN and DMN when compared with NHW\u2010PwMS. Moreover, B\u2010PwMS showed a higher degree of structure\u2013function decoupling in the SMN, with a trend towards association with increased physical disability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70331","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:41:49Z","timestamp":1770968509000},"page":"1558-1568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structure\u2013Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With\n                    <scp>MS<\/scp>"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0304-0529","authenticated-orcid":false,"given":"Emilio","family":"Cipriano","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) University of Genoa  Genoa 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Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Graziano","sequence":"additional","affiliation":[{"name":"The Corinne Goldsmith Dickinson Center for Multiple Sclerosis Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1825-8155","authenticated-orcid":false,"given":"Claire","family":"Wigley","sequence":"additional","affiliation":[{"name":"The Corinne Goldsmith Dickinson Center for Multiple Sclerosis Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Riley","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of 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