{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:54:31Z","timestamp":1788656071761,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG073100"],"award-info":[{"award-number":["R01AG073100"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013301","name":"Parkinson's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01RS003397"],"award-info":[{"award-number":["I01RS003397"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01RX001631"],"award-info":[{"award-number":["I01RX001631"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P50NS091856"],"award-info":[{"award-number":["P50NS091856"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P50NS123067"],"award-info":[{"award-number":["P50NS123067"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS144749"],"award-info":[{"award-number":["R21NS144749"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross\u2010sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ligand [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010fluoroethoxybenzovesamicol ([\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010FEOBV) binding predicts longitudinal cognitive changes in mild\u2013moderate, non\u2010demented PD subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010five non\u2010demented, mild\u2013moderate PD subjects underwent baseline [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010FEOBV PET and standardized cognitive evaluations, with repeat cognitive testing after 2\u2009years. Participants were classified into four cognitive classes: persistent normal (no MCI at either time point;\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200941), persistent MCI (MCI at both;\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200921), MCI conversion (normal to MCI;\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20096), and MCI reversion (MCI to normal;\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20097). We performed whole\u2010brain voxel comparisons (controls and between classes) and used linear and multinomial regression to predict follow\u2010up cognitive status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Whole\u2010brain voxel analyses revealed class\u2010specific [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010FEOBV binding deficits. Persistent MCI showed the most widespread reductions, extending into frontal regions. Compared with MCI reverter and persistently normal groups, persistent MCI had lower binding in occipito\u2010temporal and temporo\u2010parieto\u2010frontal regions, respectively, while MCI reverters showed higher occipital binding than converters. Binding in occipital, temporo\u2010parietal, and medial frontal regions predicted follow\u2010up cognitive decline, with medial frontal binding showing the strongest association (esp. global cognition, memory, and visuospatial domains).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Baseline cholinergic system changes associate with varying cognitive trajectories in mild\u2013moderate PD. Assessment of regional cholinergic deficits may be useful for prediction of cognitive trajectories in this population, enhancing subject selection and stratification for intervention trials aimed at improving cognition in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70335","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:31:17Z","timestamp":1770967877000},"page":"1569-1580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Taylor","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"},{"name":"Morris K. Udall Center of Excellence for Parkinson's Disease Research University of Michigan  Ann Arbor Michigan USA"},{"name":"Parkinson's Foundation Research Center of Excellence University of Michigan  Ann Arbor Michigan USA"},{"name":"Functional Neuroimaging, Cognitive, and Mobility Laboratory, Department of Radiology Ann Arbor, MI, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Carli","sequence":"additional","affiliation":[{"name":"Morris K. Udall Center of Excellence for Parkinson's Disease Research University of Michigan  Ann Arbor Michigan USA"},{"name":"Parkinson's Foundation Research Center of Excellence University of Michigan  Ann Arbor Michigan USA"},{"name":"Functional Neuroimaging, Cognitive, and Mobility Laboratory, Department of Radiology Ann Arbor, MI, University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabesh","family":"Kanel","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"},{"name":"Morris K. Udall Center of Excellence for Parkinson's Disease Research University of Michigan  Ann Arbor Michigan USA"},{"name":"Parkinson's Foundation Research Center of Excellence University of Michigan  Ann Arbor Michigan USA"},{"name":"Functional Neuroimaging, Cognitive, and Mobility Laboratory, Department of Radiology Ann Arbor, MI, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stiven","family":"Roytman","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"},{"name":"Morris K. Udall Center of Excellence for Parkinson's Disease Research University of Michigan  Ann Arbor Michigan USA"},{"name":"Parkinson's Foundation Research Center of Excellence University of Michigan  Ann Arbor Michigan USA"},{"name":"Functional Neuroimaging, Cognitive, and Mobility Laboratory, Department of Radiology Ann Arbor, MI, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimie","family":"Barr","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"},{"name":"Morris K. Udall Center of Excellence for Parkinson's Disease Research University of Michigan  Ann Arbor Michigan USA"},{"name":"Parkinson's Foundation Research Center of Excellence University of Michigan  Ann Arbor Michigan USA"},{"name":"Functional Neuroimaging, Cognitive, and Mobility Laboratory, Department of Radiology Ann Arbor, MI, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas I.","family":"Bohnen","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"},{"name":"Morris K. Udall Center of Excellence for Parkinson's Disease Research University of Michigan  Ann Arbor Michigan USA"},{"name":"Parkinson's Foundation Research Center of Excellence University of Michigan  Ann Arbor Michigan USA"},{"name":"Functional Neuroimaging, Cognitive, and Mobility Laboratory, Department of Radiology Ann Arbor, MI, University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-608X","authenticated-orcid":false,"given":"Roger L.","family":"Albin","sequence":"additional","affiliation":[{"name":"Morris K. Udall Center of Excellence for Parkinson's Disease Research University of Michigan  Ann Arbor Michigan USA"},{"name":"Parkinson's Foundation Research Center of Excellence University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"},{"name":"Neurology Service and GRECC, VA Ann Arbor Healthcare System Ann Arbor, MI  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70373-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21956"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.13"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305277"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00280-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/576091"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181306"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1392-5"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu193"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2022.01.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00377-X"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.60"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0971-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70047"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1006567"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28360"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2021.09.018"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010024\u201000872\u2010z"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28913"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60815-0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab109"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbas.2022.100039"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.1865"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.124792"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.183"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0130-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000191154.78131.f6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac320"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2018.12.020"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30032-2"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.04.032"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24541"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.19070165"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26596"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad226"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx310"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy072"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf168"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad192"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-223489"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70335","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.70335","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:06:09Z","timestamp":1786986369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.70335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/acn3.70335"],"URL":"https:\/\/doi.org\/10.1002\/acn3.70335","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"2025-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}