{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:59:39Z","timestamp":1791197979211,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA\u2010pure and PCA\u2010plus syndromes based on consensus criteria. To address this, the PCA Asia Workgroup was established to study PCA in Asian countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Asia PCA Workgroup collected demographic and clinical data, including symptoms and signs, from PCA patients. Patients were classified into PCA\u2010pure (solely meeting PCA criteria) and PCA\u2010plus (additional features of other neurodegenerative syndromes). The frequency of clinical presentations, symptoms, and signs was compared to the consensus classification estimation and the meta\u2010analysis of published data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PCA\u2010pure (76.2%) was the most common subtype, with earlier onset (80.95%) and distinct early prominent deficit of executive\/memory &gt; visual disturbances which is different from the consensus study has estimated and the meta\u2010analysis of published data. PCA\u2010Lewy body disease (PCA\u2010DLB) exhibited higher frequencies of attention deficits, visual hallucinations, cognitive fluctuations, and rigidity compared to PCA\u2010pure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>This study reveals the real\u2010world clinical presentation of PCA syndrome in an Asian population, emphasizing the differences from consensus estimations and the meta\u2010analysis of published data. Further research is needed to validate these findings and compare them with real clinical data from PCA patients of other ethnicities, in order to gain a comprehensive understanding of PCA worldwide.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70347","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:27:06Z","timestamp":1774528026000},"page":"1993-2001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Posterior Cortical Atrophy in the Asia\u2010Pacific: A Report From the\n                    <scp>PCA<\/scp>\n                    Asian Workgroup"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7488-325X","authenticated-orcid":false,"given":"Yuttachai","family":"Likitjaroen","sequence":"first","affiliation":[{"name":"Division of Neurology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7560-7224","authenticated-orcid":false,"given":"Ya\u2010Ting","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levinia","family":"Lim","sequence":"additional","affiliation":[{"name":"Dementia Research Centre Nanyang Technological University  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pai\u2010Yi","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Neurology Show Chwan Memorial Hospital  Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6422-8870","authenticated-orcid":false,"given":"Jung\u2010Lung","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Neurology New Taipei Municipal TuCheng Hospital  New Taipei City Taiwan"},{"name":"Department of Neurology Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Neuroscience Research Center, Chang\u2010Gung University  Linkou, Taoyuan Taiwan"},{"name":"Graduate Institute of Mind, Brain, &amp; Consciousness, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SangYun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University College of Medicine &amp; Clinical Neuroscience Center of Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9634-6695","authenticated-orcid":false,"given":"Wataru","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neurology and Cognitive Neuroscience Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Young","family":"Ryoo","sequence":"additional","affiliation":[{"name":"Department of Neurology Eunpyeong St. Mary's Hospital, College of Medicine, the Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8380-1561","authenticated-orcid":false,"given":"Kyoko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neurology and Cognitive Neuroscience Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9244-4298","authenticated-orcid":false,"given":"Nagaendran","family":"Kandiah","sequence":"additional","affiliation":[{"name":"Dementia Research Centre Nanyang Technological University  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Crutch","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0475-4515","authenticated-orcid":false,"given":"Ming\u2010Chyi","family":"Pai","sequence":"additional","affiliation":[{"name":"Division of Behavioral Neurology, Department of Neurology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan City Taiwan"},{"name":"Alzheimer's Disease Research Center, National Cheng Kung University Hospital  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520310107024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.3.484"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(96)00240-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.4.388"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140289.18472.15"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.207"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0712-z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140290.80962.BF"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000058331"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.01.014"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.cn-001907"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-04227-1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.82760"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00414-3"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0306-8"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.179903"},{"issue":"4","key":"e_1_2_11_20_1","first-page":"381","article-title":"Heidenhain Variant in Two Patients With Inherited V210I Creutzfeldt\u2010Jakob Disease","volume":"126","author":"Imbriani P.","year":"2016","journal-title":"International Journal of Neuroscience"},{"key":"e_1_2_11_21_1","article-title":"Visual Impairment and Posterior Cortical Atrophy Preceding Rapid Progressive Dementia","volume":"25","author":"Muller K. 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