{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:47Z","timestamp":1786988147448,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471368"],"award-info":[{"award-number":["82471368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location\u2010specific hematoma volumes for END in supratentorial ICH patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts. END was defined as a \u2265\u20094\u2010point increase in the National Institutes of Health Stroke Scale (NIHSS) score or a \u2265\u20092\u2010point decrease in the Glasgow Coma Scale score within 24\u2009h of admission. The training cohort was used to determine location\u2010specific hematoma volume cutoffs for END and to develop the location\u2010specific hematoma volume for early neurological deterioration (LIVED) score. Internal validation used 30% of the cohort, with external validation in a separate cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1199 patients with supratentorial ICH were included, divided into training (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009633), internal validation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009272), and external validation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009294) cohorts. Hematoma volume thresholds for END were 21\u2009mL for basal ganglia, 12\u2009mL for thalamus, and 32\u2009mL for lobar hemorrhages. Multivariable logistic regression identified location\u2010specific hematoma volume, right\u2010sided ICH, prior ischemic stroke, and NIHSS score as independent predictors, forming the LIVED score (range 0\u20135 points). The LIVED score showed superior predictive performance for END compared with established ICH scores, with the highest area under the curve (AUC) across cohorts. Additionally, it exhibited strong discrimination for 3\u2010month outcomes, including functional independence, poor outcomes, and mortality, with AUCs &gt;\u20090.70 in all cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Location\u2010specific hematoma volume thresholds independently predicted END, and the LIVED score demonstrated reliable performance for risk stratification in supratentorial ICH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70351","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T04:13:31Z","timestamp":1771820011000},"page":"1653-1661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Location\u2010Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-3101","authenticated-orcid":false,"given":"Zuoqiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4531-3938","authenticated-orcid":false,"given":"Guilin","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongren Hospital Shanghai Jiao Tong University, School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7974-7075","authenticated-orcid":false,"given":"Zijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1295-3293","authenticated-orcid":false,"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery The Third Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiannan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of 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