{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:11:28Z","timestamp":1783930288889,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron\u2010laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab\u2010treated patients with at least one PRL on quantitative susceptibility mapping (QSM), 97 PRLs were identified. Before treatment, PRLs showed higher QSM values than non\u2010PRLs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), indicating iron enrichment. After treatment, PRLs demonstrated a greater QSM reduction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with an accelerated decline in susceptibility. These findings suggest ocrelizumab may attenuate iron\u2010related inflammation in PRLs.\n                  <\/jats:p>","DOI":"10.1002\/acn3.70357","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:21:51Z","timestamp":1773159711000},"page":"1482-1487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0699-0134","authenticated-orcid":false,"given":"Kimberly H.","family":"Markowitz","sequence":"first","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha V.","family":"Safi","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iliana","family":"Pliska\u2010Bloch","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike W.","family":"Kaunzner","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha","family":"Luu","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mert","family":"Sisman","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh D.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hurtado R\u00faa","sequence":"additional","affiliation":[{"name":"Mathematics and Statistics Cleveland State University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4015-1781","authenticated-orcid":false,"given":"Susan A.","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine  New York New York USA"},{"name":"Department of Radiology Weill Cornell Medicine  New York New York USA"},{"name":"Feil Family Brain and Mind Institute Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2399"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08477-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12987"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001138"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606468"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22187"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51338"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25358"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.30006"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.05.044"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102854"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae013"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1545"},{"issue":"1","key":"e_1_2_11_16_1","first-page":"20","article-title":"Segmented: An R Package to Fit Regression Models With Broken\u2010Line Relationships","volume":"8","author":"Muggeo V. 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