{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:50:07Z","timestamp":1792698607961,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Plasma p\u2010217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p\u2010217tau biomarker in 12 other neurological diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma p\u2010217tau levels were measured in 298 participants, consisting of 81 AD patients, 204 patients with 12 other neurological diseases, and 13 healthy and cognitively unimpaired controls (HCU), using an assay system from Meso Scale Diagnostics. Cerebrospinal fluid (CSF) tau and A\u00df levels were simultaneously evaluated in AD, amyotrophic lateral sclerosis (ALS), and idiopathic normal pressure hydrocephalus (iNPH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Plasma p\u2010217tau levels increased in AD with the clinical stage, but also in ALS and iNPH, leading to them having decreased sensitivity and specificity for diagnosing AD. No increases in plasma p\u2010217tau levels were seen in possible tauopathies or synucleinopathies. CSF and plasma p\u2010217tau levels were strongly correlated in AD, but not in ALS. The plasma p\u2010217tau\/CSF p\u2010217tau ratio was inversely higher in ALS than in AD. Active and chronic denervation potentials were associated with plasma p\u2010217tau levels. In iNPH, plasma p\u2010217tau was associated with cognitive dysfunction, but not with gait disturbance or urinary incontinence. CSF p\u2010181tau, total tau, and A\u00df1\u201040 levels and the A\u00df1\u201040\/1\u201342 ratio were reduced in iNPH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>ALS and iNPH are two major pitfalls for the clinical application of plasma p\u2010217tau as a biomarker of AD. Lower motor neuron injury in ALS and cognitive dysfunction in iNPH were both found to be associated with elevated plasma p\u2010217tau levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70359","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:19:12Z","timestamp":1773058752000},"page":"1780-1790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Validation of Plasma p\u2010217tau in Neurological Diseases"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-6310","authenticated-orcid":false,"given":"Takeshi","family":"Kawarabayashi","sequence":"first","affiliation":[{"name":"Department of Neurology Dementia Research Center, Geriatrics Research Institute and Hospital  Maebashi Japan"},{"name":"Department of Neurology Gunma University Graduate School of Medicine  Maebashi Japan"},{"name":"Department of Social 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