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We aimed to determine the minimally clinically important difference (MCID) for CASE. Using our AE cohort, receiver operating characteristic analyses were anchored to \u2265\u20091\u2010point improvement in mRS over 3\u2010month intervals. Among 222 AE patients (65 NMDAR, 49 LGI1, and 108 seronegative AE), a 30% CASE reduction showed good discriminatory performance for mRS improvement in the first 6\u2009months, particularly in NMDAR and seronegative subgroups. 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