{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:06:37Z","timestamp":1788941197515,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019889","name":"Weston Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019889","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005565","name":"Johnson & Johnson Innovative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005565","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We therefore examined associations of CSF 3,4\u2010dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3,4\u2010dihydroxyphenylglycol (DOPEG), and 5\u2010hydroxyindoleacetic acid (5\u2010HIAA) with baseline Montreal Cognitive Assessment (MoCA) scores and with longitudinal rates of change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety\u2010five patients with early PD and fifty\u2010six demographically matched healthy controls (HCs) were included from the Parkinson's Progression Markers Initiative cohort. Baseline CSF concentrations of monoamine metabolites were measured by liquid chromatography coupled with tandem mass spectrometry (LC\u2013MS\/MS). In PD patients, multivariable linear regression and linear mixed\u2010effects models were used to evaluate the cross\u2010sectional and longitudinal associations, respectively, between baseline CSF metabolites and MoCA scores. To facilitate comparison, the levels of monoamine metabolites were converted into Z\u2010scores to attain standardized \u03b2 coefficients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with HCs, PD patients had lower baseline CSF concentrations of DOPAC, HVA, and 5\u2010HIAA. After adjustment for relevant covariates, any standardized CSF metabolite was not associated with baseline MoCA scores. Lower baseline CSF DOPAC and HVA were significantly associated with more rapid cognitive decline over time (z\u2010DOPAC: \u03b2\u2009=\u20090.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; z\u2010HVA: \u03b2\u2009=\u20090.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Neither DOPEG nor 5\u2010HIAA was associated with longitudinal cognitive decline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Taken together, our results indicated that baseline CSF DOPAC and HVA may serve as promising longitudinal predictors of cognitive decline in patients with PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70367","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:36:58Z","timestamp":1773722218000},"page":"1842-1850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CSF<\/scp>\n                    Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Jing\u2010Yu","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Xiang","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Qi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"},{"name":"Department of Neurology Henan University People's Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"},{"name":"Department of Neurology Henan University People's Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie\u2010Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"},{"name":"Department of Neurology Henan University People's Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3207-718X","authenticated-orcid":false,"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"},{"name":"Department of Neurology Henan University People's Hospital  Zhengzhou 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