{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:43:01Z","timestamp":1791657781874,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021J01788"],"award-info":[{"award-number":["2021J01788"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Stereoelectroencephalography\u2010guided radiofrequency thermocoagulation (SEEG\u2010RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug\u2010resistant focal epilepsy. Although evidence from real\u2010world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective study aimed to evaluate the seizure outcomes of SEEG\u2010RFTC in pediatric patients and identify predictive factors associated with seizure freedom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective observational study was conducted across two epilepsy centers, including 111 children with drug\u2010resistant epilepsy who underwent SEEG\u2010RFTC. Postoperative outcomes were assessed primarily by the rate of seizure freedom at the last follow\u2010up (minimum 1\u2009year). Potential predictive factors were analyzed through comparisons of clinical, neuroimaging, electrophysiological, and etiological variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All patients were followed for at least 1 year post\u2010procedure, with 73 (65.8%) achieving seizure freedom. Among 46 patients with focal cortical dysplasia, the seizure\u2010free rate was 80.4%. In 10 patients with hippocampus sclerosis, 6 (60%) were seizure\u2010free at the final follow\u2010up. Statistical analysis identified the course of illness (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and positron emission tomography (PET) findings (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) as significant predictors of seizure freedom.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SEEG\u2010RFTC is a safe procedure that yields favorable outcomes in a substantial proportion of pediatric patients with drug\u2010resistant focal epilepsy. The duration of epilepsy and PET characteristics are significantly associated with the likelihood of achieving seizure freedom. These findings highlight the potential of SEEG\u2010RFTC as a valuable therapeutic option in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70373","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:50:12Z","timestamp":1774583412000},"page":"2027-2035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Outcomes of\n                    <scp>SEEG<\/scp>\n                    \u2010Guided Radiofrequency Thermocoagulation in Children With Focal Drug\u2010Resistant Epilepsy: A Multicenter Real\u2010World Study"],"prefix":"10.1002","volume":"13","author":[{"given":"Weitao","family":"Chen","sequence":"first","affiliation":[{"name":"Pediatric Epilepsy Center Fuzhou Children's Hospital  Fuzhou 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