{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:59:09Z","timestamp":1791197949070,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>High\u2010altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene\u2010related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of the disorder due to the shared clinical presentation of migraine and HAH. This study investigated tear fluid CGRP concentrations in response to high\u2010altitude exposure and headache in healthy volunteers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective field study was conducted during a high\u2010altitude trekking expedition in the Alps. Headache and accompanying symptoms were raised using a structured questionnaire, and tear fluid samples were collected at study Day 1 (baseline, 450\u2009m), at study Day 3 (3647\u2009m), and at study Day 4 (4554\u2009m). Tear fluid CGRP concentrations were quantified using a commercial ELISA kit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirteen participants were included in the analysis. At 4554\u2009m, 61.5% of participants reported a HAH. In participants with HAH, increase of tear fluid CGRP was significantly higher compared to participants without HAH (HAH: +1.49\u2009\u00b1\u20091.74\u2009ng\/mL, no HAH: \u22120.42\u2009\u00b1\u20090.64\u2009ng\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). Increase of tear fluid CGRP levels was significantly higher in participants with a moderate\u2010to\u2010severe headache (+1.86\u2009\u00b1\u20091.86\u2009ng\/mL) compared to participants with mild headache (\u22120.19\u2009\u00b1\u20090.75\u2009ng\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The results support a potential role for CGRP in the pathophysiology of HAH. Further studies with a larger number of participants are needed to determine the mechanisms of the disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70374","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T09:11:27Z","timestamp":1774861887000},"page":"2046-2056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Calcitonin Gene\u2010Related Peptide in High\u2010Altitude Headache: A Prospective Field Study"],"prefix":"10.1002","volume":"13","author":[{"given":"Roman","family":"Schniepp","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital, LMU Munich  Munich Germany"},{"name":"Institut f\u00fcr Notfallmedizin und Medizinmanagement (INM) University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Karrasch","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Klinikum Garmisch\u2010Partenkirchen  Garmisch\u2010Partenkirchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Breitenstein","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Straube","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1891-1799","authenticated-orcid":false,"given":"Katharina","family":"Kamm","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital, LMU Munich  Munich 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