{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:59:18Z","timestamp":1791197958556,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82571516"],"award-info":[{"award-number":["No. 82571516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>High\u2010resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high\u2010resolution MRI and to examine subtype\u2010specific associations between high\u2010resolution MRI features and ischemic infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled 398 adult patients with moyamoya vasculopathy. According to high\u2010resolution MRI characteristics, 340 patients were classified as moyamoya disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009279) or atherosclerosis\u2010associated moyamoya vasculopathy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200961). Hemisphere\u2010level analyses were performed using generalized estimating equations logistic models with patients as clusters to evaluate associations between high\u2010resolution MRI measures and ischemic hemispheres.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with atherosclerosis\u2010associated moyamoya vasculopathy, moyamoya disease patients were more often female and more likely to have a family history of early\u2010onset stroke and posterior cerebral artery involvement. In the moyamoya disease group, greater middle cerebral artery stenosis, higher Suzuki stage, and more severe internal carotid artery, middle cerebral artery, and posterior cerebral artery involvement were independently associated with ischemic hemispheres, whereas a higher middle cerebral artery remodeling index was inversely associated with ischemia. In the atherosclerosis\u2010associated moyamoya vasculopathy group, higher middle cerebral artery remodeling index and more severe anterior cerebral artery involvement were independently associated with ischemic hemispheres, while other high\u2010resolution MRI metrics showed no significant associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>High\u2010resolution MRI\u2010derived quantitative vascular metrics show distinct ischemia\u2010related patterns in moyamoya disease and atherosclerosis\u2010associated moyamoya vasculopathy. Global steno\u2010occlusive burden with impaired middle cerebral artery remodeling characterizes ischemic hemispheres in moyamoya disease, whereas adverse middle cerebral artery remodeling and anterior cerebral artery involvement are key correlates of ischemia in atherosclerosis\u2010associated moyamoya vasculopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70380","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:35:35Z","timestamp":1775043335000},"page":"2057-2067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010Resolution\n                    <scp>MRI<\/scp>\n                    Revealed Different Etiology\u2010Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1794-4358","authenticated-orcid":false,"given":"Guangsong","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachun","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehui","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, State Key Laboratory of Complex Severe and Rare 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7877-612X","authenticated-orcid":false,"given":"Jun","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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