{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:31:08Z","timestamp":1783517468594,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre\u2010existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective, two\u2010center study involved 310 patients who underwent MT for ischemic stroke and presented with impaired renal function at baseline (eGFR &lt;\u200960\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ). AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria and categorized as post\u2010contrast AKI (PC\u2010AKI), which occurred within 48 h following contrast administration, and late\u2010onset AKI (L\u2010AKI), which developed later during hospitalization. We analyzed the clinical and laboratory factors that might predispose patients to the development of AKI and compared the clinical profiles of those with PC\u2010AKI and L\u2010AKI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acute kidney injury occurred in 91 patients, including 49 with PC\u2010AKI and 42 with L\u2010AKI. Patients who developed AKI were more likely to have pre\u2010existing chronic kidney disease, prior NSAIDs use, and higher serum glucose and potassium levels at admission. Additionally, AKI was associated with longer hospitalization, increased in\u2010hospital and 3\u2010month mortality, and less favorable clinical outcomes overall. The independent predictors of AKI included NIHSS &gt;\u200915 (OR: 3.441), WBC count (OR: 1.128), female sex (OR: 0.311), and the comorbidity burden (OR: 2.414).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Acute kidney injury represents a frequent and clinically relevant complication following MT in patients with pre\u2010existing renal impairment. Early recognition and the implementation of preventive strategies are essential, particularly in patients with established risk factors for AKI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70391","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:12:39Z","timestamp":1783516359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre\u2010Existing Renal Impairment"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8777-0997","authenticated-orcid":false,"given":"Micha\u0142","family":"Boro\u0144czyk","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Health Sciences Medical University of Silesia in Katowice  Katowice Poland"},{"name":"Department of Neurology Upper\u2010Silesian Medical Centre  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Pilarek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Health Sciences Medical University of Silesia in Katowice  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Jaworska","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medical Science Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Kardas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Health Sciences Medical University of Silesia in Katowice  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliwia","family":"Barna\u015b","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Health Sciences Medical University of Silesia in Katowice  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Wo\u017aniak","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Health Sciences Medical University of Silesia in Katowice  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iga","family":"Macha\u0142a","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medical Science Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"W\u0119grzynek\u2010Gallina","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medical Science Medical University of Silesia  Katowice Poland"},{"name":"Department of Neurology University Clinical Centre Prof. K. 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