{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:57:57Z","timestamp":1775807877292,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009160","name":"Universit\u00e9 Toulouse III - Paul Sabatier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009160","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006556","name":"Centre Hospitalier Universitaire de Toulouse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010962","name":"Institut des Sciences du Cerveau de Toulouse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network\u2010level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their longitudinal evolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, single\u2010center case\u2013control study of 20 patients with acute TGA and 20 age\u2010 and sex\u2010matched healthy controls. All participants completed neuropsychological testing and underwent structural and functional MRI at three time points: acute phase (&lt;\u200924\u2009h from onset), day 3, and 3\u2009months. Primary outcomes were neuropsychological performance across episodic, semantic, and metamemory domains and resting\u2010state fMRI connectivity within the episodic memory network. Secondary outcomes were functional connectivity within the Default Mode (DMN), Executive (ECN), and Salience (SN) networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 40 participants were included (20 patients with TGA, mean age 65.5\u2009years, 45% women; 20 controls, mean age 64.3\u2009years, 45% women). In patients, median delay from symptoms' onset to MRI was 6.67\u2009h. Neuropsychologically, patients showed profound multimodal anterograde amnesia during the acute phase, resolving by 3\u2009months. This deficit was largely isolated, sparing semantic memory and metamemory. Structurally, small bilateral lesions were present in most patients. Functionally, acute hypoconnectivity was observed within the extended hippocampal system, particularly between parahippocampal and cingulate cortices, normalizing by 3\u2009months. No consistent disruption was found in large\u2010scale networks (default mode, executive control, salience).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>TGA is associated with transient, selective hypoconnectivity within the mesiotemporal\u2013cingulate episodic memory network, aligning with previous reports and further precising the functional anatomy. The finding of a profound anterograde amnesia was replicated and its recovery timecourse was elucidated. Semantic memory and metamemory remain preserved, clarifying inconsistencies in prior reports. These findings suggest that TGA reflects a transient limbic dysconnectivity syndrome rather than a diffuse network disorder, reconciling structural lesions with clinical and functional data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70396","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:16:10Z","timestamp":1775805370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Memory and Resting\u2010State Connectivity in Acute Transient Global Amnesia: A Case\u2013Control\n                    <scp>fMRI<\/scp>\n                    Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7776-4816","authenticated-orcid":false,"given":"Elias","family":"El Otmani","sequence":"first","affiliation":[{"name":"ToNIC Toulouse NeuroImaging Center, UMR 1214, Universit. De Toulouse, INSERM, Paul Sabatier University (UT3)  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Barbeau","sequence":"additional","affiliation":[{"name":"CNRS, Cerco  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Lemesle","sequence":"additional","affiliation":[{"name":"Department of Neurology Neuroscience Centre, Toulouse\u2010Purpan University Hospital  Toulouse Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Milongo\u2010Rigal","sequence":"additional","affiliation":[{"name":"Department of Neurology Neuroscience Centre, Toulouse\u2010Purpan University Hospital  Toulouse Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University Hospital of Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Charpentier","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University Hospital of Toulouse  Toulouse France"},{"name":"Laboratory of Epidemiology and Analyses in Public Health UMR 1295 Inserm, Toulouse University  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Albucher","sequence":"additional","affiliation":[{"name":"ToNIC Toulouse NeuroImaging Center, UMR 1214, Universit. De Toulouse, INSERM, Paul Sabatier University (UT3)  Toulouse France"},{"name":"Department of Neurolog Clinical Investigation Center, CIC1436, Toulouse University Hospital  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-4445","authenticated-orcid":false,"given":"Nicolas","family":"Raposo","sequence":"additional","affiliation":[{"name":"ToNIC Toulouse NeuroImaging Center, UMR 1214, Universit. De Toulouse, INSERM, Paul Sabatier University (UT3)  Toulouse France"},{"name":"Department of Neurolog Clinical Investigation Center, CIC1436, Toulouse University Hospital  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Bonneville","sequence":"additional","affiliation":[{"name":"ToNIC Toulouse NeuroImaging Center, UMR 1214, Universit. 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