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We used magnetic resonance imaging to study radiation\u2010induced necrosis of atypical onset, severity, and extent following stereotactic radiosurgery for a symptomatic arteriovenous malformation. Susceptibility\u2010sensitive imaging, T<jats:sub>1<\/jats:sub>\u2010relaxation, myelin water imaging, and magnetic resonance spectroscopy were acquired three times up to 52\u00a0months postradiosurgery. Increasing water content outside the radiation field, contralateral neuronal loss, and gliosis were detected over time. Our findings suggest that radiation\u2010induced vasculopathic changes spread more diffusely than previously described. An autoimmune response to brain antigens could underlie white matter changes outside the initial radiation field.<\/jats:p>","DOI":"10.1002\/acn3.704","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T06:40:19Z","timestamp":1544510419000},"page":"379-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Longitudinal advanced <scp>MRI<\/scp> case report of white matter radiation necrosis"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5236-3039","authenticated-orcid":false,"given":"Vanessa","family":"Wiggermann","sequence":"first","affiliation":[{"name":"Department of Physics and Astronomy University of British Columbia Vancouver British Columbia Canada"},{"name":"Department of Pediatrics University of British Columbia Vancouver British Columbia Canada"},{"name":"UBC MRI Research Centre University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8732-1872","authenticated-orcid":false,"given":"Emmanuelle","family":"Lapointe","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Neurology University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6667-5460","authenticated-orcid":false,"given":"Ludmila","family":"Litvin","sequence":"additional","affiliation":[{"name":"Department of Radiology University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4281-3432","authenticated-orcid":false,"given":"Carina","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of British Columbia Vancouver British Columbia Canada"},{"name":"International Collaboration on Repair Discoveries (ICORD) University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-5693","authenticated-orcid":false,"given":"Enedino","family":"Hern\u00e1ndez\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of British Columbia Vancouver British Columbia Canada"},{"name":"UBC MRI Research Centre University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Radiation Oncology and Developmental Radiotherapeutics University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M.","family":"Vavasour","sequence":"additional","affiliation":[{"name":"UBC MRI Research Centre University of British Columbia Vancouver British Columbia Canada"},{"name":"Department of Radiology University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9785-6918","authenticated-orcid":false,"given":"Cornelia","family":"Laule","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of British Columbia Vancouver British Columbia Canada"},{"name":"Department of Radiology University of British Columbia Vancouver British Columbia Canada"},{"name":"International Collaboration on Repair Discoveries (ICORD) University of British Columbia Vancouver British Columbia Canada"},{"name":"Department of Pathology &amp; Laboratory Medicine University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-5858","authenticated-orcid":false,"given":"Erin L.","family":"MacMillan","sequence":"additional","affiliation":[{"name":"UBC MRI Research Centre University of British Columbia Vancouver British Columbia Canada"},{"name":"Department of Radiology University of British Columbia Vancouver British Columbia Canada"},{"name":"Philips Markham Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-5571","authenticated-orcid":false,"given":"David K. 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