{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:11:25Z","timestamp":1783930285180,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Traumatic spinal cord injury (TSCI) caused by sharp\u2010force penetration is exceptionally rare, and the use of high\u2010dose methylprednisolone (MP) remains highly controversial, especially beyond the conventional 8\u2010h treatment window. This case report describes a 30\u2010year\u2010old male with acute incomplete TSCI following a knife stab wound to the right neck. Despite no initial improvement, high\u2010dose MP (1000\u2009mg\/day for 3\u2009days, tapered thereafter) was initiated 40\u2009h post\u2010injury, along with mannitol. Remarkable neurological recovery was observed, including independent ambulation by post\u2010injury day 25. Follow\u2010up MRI showed significant hematoma absorption. This case suggests that delayed high\u2010dose MP may benefit selected TSCI patients, particularly those with penetrating mechanisms and ongoing secondary injury. It highlights the potential for extending the therapeutic window in specific scenarios and supports the need for further research into individualized treatment strategies for TSCI.<\/jats:p>","DOI":"10.1002\/acn3.70405","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:49:40Z","timestamp":1776833380000},"page":"1503-1506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remarkable Recovery After Delayed High\u2010Dose Methylprednisolone in a Rare Case of Penetrating Spinal Cord Injury"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7847-6019","authenticated-orcid":false,"given":"Honghong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine The People's Hospital of YuHuan  Taizhou, Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture The First Affiliated Hospital of Wenzhou Medical University  Wenzhou, Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Acupuncture The First Affiliated Hospital of Wenzhou Medical University  Wenzhou, Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Acupuncture The First Affiliated Hospital of Wenzhou Medical University  Wenzhou, Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Acupuncture The First Affiliated Hospital of Wenzhou Medical University  Wenzhou, Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongheng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Acupuncture The First Affiliated Hospital of Wenzhou Medical University  Wenzhou, Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4192"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0715-4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30415-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2016.1177348"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2192568217703085"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.184450"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005173222001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540440031029"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000430319.32247.7f"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/21925682231202348"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911740"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.70405","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:47:20Z","timestamp":1783928840000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.70405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/acn3.70405"],"URL":"https:\/\/doi.org\/10.1002\/acn3.70405","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"2025-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}