{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:12:37Z","timestamp":1790097157475,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) have demonstrated significant weight\u2010reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non\u2010arteritic anterior ischemic optic neuropathy (NAION) have emerged. Hence, this study was designed to examine the relationship between GLP\u20101 RA use and optic outcomes in IIH patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study used the TriNetX Global Collaborative Network to perform a retrospective propensity score\u2010matched cohort study. It involved GLP\u20101 RA exposure status to classify adult patients with IIH. Further, it applied propensity score matching (PSM) on demographics, comorbidities, and medications. In this study, the primary outcome was incident NAION; the secondary outcome was optic atrophy. Cox proportional hazards regression, time\u2010stratified analyses, and multiple testing corrections were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 144,678 IIH patients, 15,567 matched pairs were analyzed. GLP\u20101 RA use demonstrated significantly decreased NAION risk (hazard ratio [HR] 0.47, 95% confidence interval [CI] 0.24\u20130.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027) and optic atrophy risk (HR 0.78, 95% CI 0.64\u20130.94,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Time\u2010stratified analyses have demonstrated protective associations across all evaluated time windows. The optic atrophy finding remained significant after Bonferroni correction, while NAION remained significant after false discovery rate correction. Subgroup analysis revealed stronger protective associations in non\u2010diabetic patients (risk ratio 0.53, 95% CI 0.41\u20130.68) compared to diabetic patients (risk ratio 0.76, 95% CI 0.58\u20130.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 RA utilization among IIH patients was associated with a reduced risk of NAION and optic atrophy. These findings align with the proposed pathway linking GLP\u20101 RA\u2010induced weight reduction to lower intracranial pressure and papilledema reduction in IIH patients; residual confounding cannot be ruled out, and prospective studies are needed to confirm these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70406","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T10:42:37Z","timestamp":1776422557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk of Non\u2010Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonists"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7741-4670","authenticated-orcid":false,"given":"Faisal A.","family":"Al\u2010Harbi","sequence":"first","affiliation":[{"name":"College of Medicine Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5412-046X","authenticated-orcid":false,"given":"Mohanad A.","family":"Alkuwaiti","sequence":"additional","affiliation":[{"name":"College of Medicine Imam Abdulrahman Bin Faisal University  Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazeed B.","family":"Alaql","sequence":"additional","affiliation":[{"name":"College of Medicine Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed K.","family":"Alsaif","sequence":"additional","affiliation":[{"name":"College of Medicine Al\u2010Rayan Colleges  Al\u2010Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Alessa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meshari Ayed","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Qassim Health Cluster  Qassim Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alfalah","sequence":"additional","affiliation":[{"name":"College of Medicine King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saud A.","family":"Alnaaim","sequence":"additional","affiliation":[{"name":"College of Medicine King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad M.","family":"AlHaddad","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes King Fahad Medical City (KFMC)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4256-0159","authenticated-orcid":false,"given":"Ahmed Y.","family":"Azzam","sequence":"additional","affiliation":[{"name":"Director of Clinical Research and Clinical Artificial Intelligence, ASIDE Healthcare  Lewes Delaware USA"},{"name":"Division of Global Health and Public Health, School of Nursing, Midwifery and Public Health University of Suffolk  Ipswich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.71079\/aside.im.0000012282413"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2024.102057"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/vision7040072"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000214335"},{"issue":"7","key":"e_1_2_10_6_1","first-page":"718","article-title":"Awareness, Diagnosis and Management of Idiopathic Intracranial Hypertension","volume":"11","author":"Jensen R. 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