{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:44:17Z","timestamp":1777117457949,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Neuralgic amyotrophy (\n                      <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\n                      ) is a prevalent, monophasic, multifocal immune\u2010mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (\n                      <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\n                      \u2010associated focal nerve lesions,\n                      <jats:styled-content style=\"fixed-case\">NAFL<\/jats:styled-content>\n                      ). The pathophysiology underlying this phenomenon remains to be fully elucidated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study uses an observational research design with a single center, retrospective approach. We evaluated patients who presented at the outpatient clinic of a tertiary referral hospital between January 1, 2022, and August 5, 2025, due to NA. In addition to evaluating clinical and neurophysiological data, two independent experts examined the available ultrasound images for the prevalence of NAFL and the presence of arterial vascular structures in the immediate vicinity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 171 affected nerves from 77 patients were analyzed. The prevalence of NAFL was 31% (24\/77) among all patients. In 53% of all NAFL, direct neurovascular contact could be detected. A previous mechanical trigger was identified in 71% of patients with proven NAFL but without neurovascular contact. This was the case in only 29% of patients with neurovascular contact, although this discrepancy did not attain statistical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The frequency of neurovascular contacts in close proximity to NAFL suggests that these contacts play a role in its pathophysiology. Such contacts, similar to mechanical tension on the nerve, could lead to a local disruption of the blood\u2013nerve barrier. This would explain phenomena inconsistent with the current pathophysiological model, such as the lack of preference for the dominant arm and NAFL's occurrence at certain anatomical sites.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70416","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:22:16Z","timestamp":1777116136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2140-906X","authenticated-orcid":false,"given":"Johannes Fabian","family":"Holle","sequence":"first","affiliation":[{"name":"Health Faculty\/Department for Human Medicine University of Witten\/Herdecke  Germany"},{"name":"Department of Neurology, Cologne\u2010Merheim Hospitals of the City of Cologne Cologne  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Leha","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics University Medical Center G\u00f6ttingen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Limmroth","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cologne\u2010Merheim Hospitals of the City of Cologne Cologne  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Windisch","sequence":"additional","affiliation":[{"name":"Health Faculty\/Department for Human Medicine University of Witten\/Herdecke  Germany"},{"name":"Cologne\u2010Merheim Lung Clinic Hospitals of the City of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Health Faculty\/Department for Human Medicine University of Witten\/Herdecke  Germany"},{"name":"Cologne\u2010Merheim Lung Clinic Hospitals of the City of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"483","article-title":"Neuralgic Amyotrophy: A Commonly Overlooked Cause of Acute Shoulder Pain","volume":"121","author":"Holle J. 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