{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:47Z","timestamp":1786988147501,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 44\u2010year\u2010old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome. We describe the pathophysiologic basis of central thermoregulation and an approach to the assessment and management of patients presenting with disorders thereof, including the importance of considering central thermoregulatory failure after systemic disease has been carefully excluded.<\/jats:p>","DOI":"10.1002\/acn3.70419","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:35:58Z","timestamp":1777455358000},"page":"1719-1725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5880-4920","authenticated-orcid":false,"given":"Naveen","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Neurology King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurology King's College Hospital  London UK"},{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Neurology King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin","family":"Mulroy","sequence":"additional","affiliation":[{"name":"Department of Neurology King's College Hospital  London UK"},{"name":"Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/isbn.978-3-8055-8649-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/272333a0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00668.2006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/317521"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.02.011"},{"issue":"3","key":"e_1_2_8_7_1","first-page":"305","article-title":"Out of the Cold: Management of Hypothermia and Frostbite","volume":"168","author":"Biem J.","year":"2003","journal-title":"Canadian Medical Association Journal"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13121690"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2023.06.037"},{"key":"e_1_2_8_10_1","first-page":"321","volume-title":"Handbook of Clinical Neurology","author":"Fealey R. 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