{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:41:02Z","timestamp":1791841262839,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Isolated rapid\u2010eye\u2010movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video\u2010polysomnography. We assessed a two\u2010stage screening strategy combining a brief questionnaire on rapid\u2010eye\u2010movement sleep behavior disorder symptoms and other prodromes with wrist actigraphy across multiple case\u2013control cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants aged 40\u201380 without neurodegenerative disease were recruited from five cohorts; all cases were confirmed by video\u2010polysomnography. The questionnaire was administered to 289 participants, and 236 underwent \u2265\u200914 nights of home wrist actigraphy. The wearable\u2010based algorithm was built on four movement features (mean motor activity, activity index, short or long immobile bouts, twitch activity). Models were trained with nested cross\u2010validation using XGBoost.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The full retrospective cohort included 396 participants (99 cases, 297 controls; mean age 64\u2009\u00b1\u200911; 55% male). The dream enactment question alone achieved an area under the curve of 0.85, which improved to 0.86 using the four\u2010item questionnaire. Actigraphy alone achieved 82% sensitivity and 84% specificity. In the subgroup completing both assessments (75 cases, 54 controls), the two\u2010stage protocol\u2014questionnaire followed by actigraphy\u2014yielded 68% sensitivity and 100% specificity using the dream enactment question alone, and 73% sensitivity and 100% specificity using the four\u2010item questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>A two\u2010stage protocol combining questionnaire and actigraphy demonstrated high specificity and good sensitivity for detecting isolated rapid\u2010eye\u2010movement sleep behavior disorder in this multicenter cohort. This low\u2010cost, scalable strategy is compatible with widely used wearable devices and warrants validation in community\u2010based populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70439","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:10:21Z","timestamp":1779509421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Two\u2010Stage Questionnaire and Actigraphy Screening for\n                    <scp>iRBD<\/scp>\n                    in a Multicenter Retrospective Cohort"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8058-7138","authenticated-orcid":false,"given":"Caleb A.","family":"Massimi","sequence":"first","affiliation":[{"name":"Department of Neurology Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio Ricciardiello","family":"Mejia","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Metzger","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Hyun","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salonee","family":"Marwaha","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Grzegorczyk","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Gilyadov","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Kunney","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqhwa","family":"Ncube","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine Icahn School of Medicine  New York New York USA"},{"name":"Department of Artificial Intelligence and Human Health Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Mignot","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Division of Sleep Medicine Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny M.","family":"Elahi","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4069-3158","authenticated-orcid":false,"given":"Joseph","family":"Winer","sequence":"additional","affiliation":[{"name":"Department of Neurology Stanford University  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3424-7143","authenticated-orcid":false,"given":"Kathleen","family":"Poston","sequence":"additional","affiliation":[{"name":"Department of Neurology Stanford University  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Brink\u2010Kjaer","sequence":"additional","affiliation":[{"name":"Department of Health Technology Technical University of Denmark  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel H.","family":"During","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine  New York New York USA"},{"name":"Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine Icahn School of Medicine  New York New York USA"},{"name":"Department of Artificial Intelligence and Human Health Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1474-4422(23)00109-6","article-title":"Assessment of Heterogeneity Among Participants in the Parkinson's Progression Markers Initiative Cohort Using \u03b1\u2010Synuclein Seed Amplification: A Cross\u2010Sectional Study","volume":"22","author":"Siderowf A.","year":"2023","journal-title":"Lancet 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