{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:11:36Z","timestamp":1783761096443,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W00710X\/1"],"award-info":[{"award-number":["MR\/W00710X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W016095\/1"],"award-info":[{"award-number":["MR\/W016095\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W030098\/1"],"award-info":[{"award-number":["MR\/W030098\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["UKDRI\u20107201"],"award-info":[{"award-number":["UKDRI\u20107201"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with Alzheimer's disease (AD,\n n<\/jats:italic>\n \u2009=\u200931), idiopathic normal pressure hydrocephalus (iNPH,\n n<\/jats:italic>\n \u2009=\u200926), and traumatic brain injury (TBI,\n n<\/jats:italic>\n \u2009=\u200923) completed online cognitive tasks (Cognitron). We evaluated cognition relative to a large normative dataset (\n N<\/jats:italic>\n \u2009\u2248\u2009400,000), adjusting for device and demographics which can affect performance. Principal Component Analysis (PCA) was used to derive domain\u2010specific and total composite scores. We compared clinical groups and correlated performance with standard assessments.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Uptake was ~70%. PCA identified components across memory, processing speed, language, and executive functions. AD showed memory and language impairments compared with the norms and other groups. iNPH had greater executive and processing speed deficits, consistent with a subcortical impairment profile. TBI showed milder deficits in memory, working memory, and language. Cognitron total composite was associated with standard supervised tests (ADAS\u2010Cog:\n \u03b2<\/jats:italic>\n \u2009=\u2009\u22120.76,\n p<\/jats:italic>\n \u2009<\u20090.001 and ACE\u2010III:\n \u03b2<\/jats:italic>\n \u2009=\u20090.69,\n p<\/jats:italic>\n \u2009<\u20090.001). In iNPH, Cognitron composite predicted walking speed (estimate\u2009=\u20091.10,\n p<\/jats:italic>\n \u2009<\u20090.001), a core clinical feature of the disease which is difficult to evaluate remotely. We selected five tasks with high completion rates, discriminability between conditions, and broad cognitive coverage. The derived short composite showed very high accuracy in separating AD (AUC\u2009=\u20090.94) and iNPH (AUC\u2009=\u20090.90) from age\u2010matched norms; performance was weaker for TBI (AUC\u2009=\u20090.66).\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n Online assessment in older clinical populations is feasible and sensitive to subtle disease\u2010specific cognitive deficits. A demographically adjusted, 15\u2010min battery offers a scalable adjunct to standard testing, with potential to reduce burden on patients and healthcare systems.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acn3.70451","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:11:42Z","timestamp":1783757502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3476-8494","authenticated-orcid":false,"given":"Martina","family":"Del Giovane","sequence":"first","affiliation":[{"name":"Department of Brain Sciences Imperial College London London UK"},{"name":"UK Dementia Research Institute Care Research and Technology Centre, Sir Michael Uren Hub Imperial College London London UK"},{"name":"Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Giunchiglia","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences Imperial College London London UK"},{"name":"Department of Biomedical Informatics Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C. B.","family":"David","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences Imperial College London London UK"},{"name":"UK Dementia Research Institute Care Research and Technology Centre, Sir Michael Uren Hub Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena A.","family":"Kolanko","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences Imperial College London London UK"},{"name":"UK Dementia Research Institute Care Research and Technology Centre, Sir Michael Uren Hub Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Trender","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Hellyer","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmeena","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Sharp","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences Imperial College London London UK"},{"name":"UK Dementia Research Institute Care Research and Technology Centre, Sir Michael Uren Hub Imperial College London London UK"},{"name":"Department of Neurology Imperial College Healthcare NHS Trust, Charing Cross Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9007-7017","authenticated-orcid":false,"given":"Christopher","family":"Carswell","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences Imperial College London London UK"},{"name":"Department of Neurology Imperial College Healthcare NHS Trust, Charing Cross Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-0780","authenticated-orcid":false,"given":"Paresh A.","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences Imperial College London London UK"},{"name":"UK Dementia Research Institute Care Research and Technology Centre, Sir Michael Uren Hub Imperial College London London UK"},{"name":"Department of Neurology Imperial College Healthcare NHS Trust, Charing Cross Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Hampshire","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences Imperial College London London UK"},{"name":"Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5770\/cgj.21.297","article-title":"The Lost Years: Delay Between the Onset of Cognitive Symptoms and Clinical Assessment at a Memory Clinic","volume":"21","author":"Claveau J.\u2010S.","year":"2018","journal-title":"Canadian Geriatrics Journal"},{"issue":"8","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/gps.1355","article-title":"The Need for a Consensus in the Use of Assessment Tools for Alzheimer's Disease: The Feasibility Study (Assessment Tools for Dementia in Alzheimer Centres Across Europe), a European Alzheimer's Disease Consortium's (EADC) Survey","volume":"20","author":"Paulino Ramirez Diaz S.","year":"2005","journal-title":"International Journal of Geriatric Psychiatry"},{"issue":"2","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1468-1331.2010.03134.x","article-title":"The Use of Neuropsychological Tests Across Europe: The Need for a Consensus in the Use of Assessment Tools for Dementia","volume":"18","author":"Maruta C.","year":"2011","journal-title":"European Journal of Neurology"},{"issue":"2","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14572","article-title":"Remote Cognitive Tests Predict Neurodegenerative Biomarkers in the Insight 46 Cohort","volume":"21","author":"Del Giovane M.","year":"2025","journal-title":"Alzheimer's & Dementia"},{"issue":"3","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3233\/JAD-160766","article-title":"Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study","volume":"60","author":"Reijs B. L. R.","year":"2017","journal-title":"Journal of Alzheimer's Disease"},{"issue":"14","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1017\/S0033291720001142","article-title":"Changes in Visual Memory in Mild Cognitive Impairment: A Longitudinal Study With CANTAB","volume":"51","author":"Campos\u2010Magdaleno M.","year":"2021","journal-title":"Psychological Medicine"},{"issue":"12","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70966","article-title":"Acceptable Standards for Clinic\u2010Based Digital Cognitive Assessments: Recommendations From the Global CEO Initiative on Alzheimer's Disease","volume":"21","author":"Thompson L. I.","year":"2025","journal-title":"Alzheimer's & Dementia"},{"issue":"1","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/1533317514522852","article-title":"Computerized Cognitive Testing for Older Adults","volume":"30","author":"Zygouris S.","year":"2015","journal-title":"American Journal of Alzheimer's Disease and Other Dementias"},{"issue":"4","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0028-3932(94)00127-B","article-title":"Is Semantic Memory Consistently Impaired Early in the Course of Alzheimer's Disease? Neuroanatomical and Diagnostic Implications","volume":"33","author":"Hodges J.","year":"1995","journal-title":"Neuropsychologia"},{"issue":"1","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in Early Alzheimer's Disease","volume":"388","author":"Dyck C. H.","year":"2023","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/pn\u20102021\u2010003291"},{"issue":"4","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1600-0404.2012.01644.x","article-title":"Counting\u2010Backward Test for Executive Function in Idiopathic Normal Pressure Hydrocephalus","volume":"126","author":"Kanno S.","year":"2012","journal-title":"Acta Neurologica Scandinavica"},{"issue":"2","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000090510","article-title":"Cognitive Impairment in Patients With Idiopathic Normal Pressure Hydrocephalus","volume":"21","author":"Ogino A.","year":"2006","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"issue":"6","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1227\/01.neu.0000306100.83882.81","article-title":"The Neuropsychology of Patients With Clinically Diagnosed Normal Pressure Hydrocephalus","volume":"61","author":"Hellstr\u00f6m P.","year":"2007","journal-title":"Neurosurgery"},{"issue":"3","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1227\/neu.0000000000002225","article-title":"Placebo\u2010Controlled Effectiveness of Idiopathic Normal Pressure Hydrocephalus Shunting: A Randomized Pilot Trial","volume":"92","author":"Luciano M.","year":"2023","journal-title":"Neurosurgery"},{"issue":"5","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/neuros\/nyaa199","article-title":"Prevalence of Alternative Diagnoses and Implications for Management in Idiopathic Normal Pressure Hydrocephalus Patients","volume":"87","author":"Macki M.","year":"2020","journal-title":"Neurosurgery"},{"issue":"4","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/mdc3.12335","article-title":"A Review of Clinical Outcomes for Gait and Other Variables in the Surgical Treatment of Idiopathic Normal Pressure Hydrocephalus","volume":"3","author":"Shaw R.","year":"2016","journal-title":"Movement Disorders Clinical Practice"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"e458","DOI":"10.1016\/j.wneu.2019.05.183","article-title":"Long\u2010Term Efficacy of Shunt Therapy in Idiopathic Normal Pressure Hydrocephalus","volume":"129","author":"Grasso G.","year":"2019","journal-title":"World Neurosurgery"},{"issue":"1","key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000520966","article-title":"Traumatic Brain Injury and Risk of Dementia and Alzheimer's Disease: A Systematic Review and Meta\u2010Analysis","volume":"56","author":"Gu D.","year":"2022","journal-title":"Neuroepidemiology"},{"issue":"9","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1001\/jamaneurol.2016.1948","article-title":"Association of Traumatic Brain Injury With Late\u2010Life Neurodegenerative Conditions and Neuropathologic Findings","volume":"73","author":"Crane P. K.","year":"2016","journal-title":"JAMA Neurology"},{"issue":"9","key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1017\/S1355617718000346","article-title":"Neuropsychological Recovery Trajectories in Moderate to Severe Traumatic Brain Injury: Influence of Patient Characteristics and Diffuse Axonal Injury\u2014Erratum","volume":"25","author":"Rabinowitz A. R.","year":"2019","journal-title":"Journal of the International Neuropsychological Society"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/med\/9780199655946.003.0039","volume-title":"Oxford Textbook of Cognitive Neurology and Dementia","author":"Sharp D. J.","year":"2016"},{"issue":"5","key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1080\/09602011.2017.1313748","article-title":"A Meta\u2010Analysis of Task\u2010Related Influences in Prospective Memory in Traumatic Brain Injury","volume":"29","author":"Wong Gonzalez D.","year":"2019","journal-title":"Neuropsychological Rehabilitation"},{"issue":"2","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/practneurol-2021-003056","article-title":"Post\u2010Traumatic Amnesia","volume":"22","author":"Parker T. D.","year":"2022","journal-title":"Practical Neurology"},{"issue":"12","key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.apmr.2008.10.002","article-title":"Recovery of Cognitive Function After Traumatic Brain Injury: A Multilevel Modeling Analysis of Canadian Outcomes","volume":"89","author":"Christensen B. K.","year":"2008","journal-title":"Archives of Physical Medicine and Rehabilitation"},{"issue":"9","key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/acn3.51849","article-title":"Using Home Monitoring Technology to Study the Effects of Traumatic Brain Injury in Older Multimorbid Adults","volume":"10","author":"Parkinson M. E.","year":"2023","journal-title":"Annals of Clinical Translational Neurology"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.101980","article-title":"Computerised Cognitive Assessment in Patients With Traumatic Brain Injury: An Observational Study of Feasibility and Sensitivity Relative to Established Clinical Scales","volume":"59","author":"Del Giovane M.","year":"2023","journal-title":"EClinicalMedicine"},{"issue":"1","key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1186\/s13063-022-06190-3","article-title":"Noradrenergic Add\u2010On Therapy With Extended\u2010Release Guanfacine in Alzheimer's Disease (NorAD): Study Protocol for a Randomised Clinical Trial and COVID\u201019 Amendments","volume":"23","author":"Hoang K.","year":"2022","journal-title":"Trials"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised Criteria for Diagnosis and Staging of Alzheimer's Disease: Alzheimer's Association Workgroup","volume":"20","author":"Jack C. R.","year":"2024","journal-title":"Alzheimer's & Dementia"},{"issue":"9","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1089\/neu.2006.0245","article-title":"The Mayo Classification System for Traumatic Brain Injury Severity","volume":"24","author":"Malec J. F.","year":"2007","journal-title":"Journal of Neurotrauma"},{"issue":"1","key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.1038\/s41467-025-62156-4","article-title":"Large\u2010Scale Online Assessment Uncovers a Distinct Multiple Sclerosis Subtype With Selective Cognitive Impairment","volume":"16","author":"Lerede A.","year":"2025","journal-title":"Nature Communications"},{"issue":"9","key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1056\/NEJMoa2311330","article-title":"Cognition and Memory After Covid\u201019 in a Large Community Sample","volume":"390","author":"Hampshire A.","year":"2024","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41746-024-01124-6","article-title":"Online Cognitive Monitoring Technology for People With Parkinson's Disease and REM Sleep Behavioural Disorder","volume":"7","author":"B\u0103l\u0103e\u0163 M.","year":"2024","journal-title":"NPJ Digital Medicine"},{"issue":"3","key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JAD-2008-15312","article-title":"Administration and Scoring Variance on the ADAS\u2010Cog","volume":"15","author":"Connor D. J.","year":"2008","journal-title":"Journal of Alzheimer's Disease"},{"issue":"3","key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000351671","article-title":"Validation of the Addenbrooke's Cognitive Examination III in Frontotemporal Dementia and Alzheimer's Disease","volume":"36","author":"Hsieh S.","year":"2013","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","unstructured":"A.Hampshire \u201cGreat British Intelligence Test Protocol \u201dPreprint at Research Square (2020) https:\/\/doi.org\/10.21203\/rs.3.pex\u20101085\/v.","DOI":"10.21203\/rs.3.pex-1085\/v1"},{"issue":"5","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1590\/0004-282x20180037","article-title":"Gait in Normal Pressure Hydrocephalus: Characteristics and Effects of the CSF Tap Test","volume":"76","author":"Souza R. K. M.","year":"2018","journal-title":"Arquivos de Neuro\u2010Psiquiatria"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102086","article-title":"The Effects of COVID\u201019 on Cognitive Performance in a Community\u2010Based Cohort: A COVID Symptom Study Biobank Prospective Cohort Study","volume":"62","author":"Cheetham N. J.","year":"2023","journal-title":"EClinicalMedicine"},{"issue":"1","key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1192\/bjb.2023.27","article-title":"Cut\u2010Off Scores for Mild and Moderate Dementia on the Addenbrooke's Cognitive Examination\u2010III and the Mini\u2010Addenbrooke's Cognitive Examination Compared With the Mini\u2010Mental State Examination","volume":"48","author":"McCarthy L.","year":"2024","journal-title":"BJPsych Bulletin"},{"issue":"8","key":"e_1_2_10_41_1","first-page":"493","article-title":"[Diagnostic Value and Functional Correlations of the ADAS\u2010Cog Scale in Alzheimer's Disease: Data on NORMACODEM Project]","volume":"22","author":"Monllau A.","year":"2007","journal-title":"Neurolog\u00eda"},{"issue":"1","key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jalz.2018.08.005","article-title":"Understanding Disease Progression and Improving Alzheimer's Disease Clinical Trials: Recent Highlights From the Alzheimer's Disease Neuroimaging Initiative","volume":"15","author":"Veitch D. P.","year":"2019","journal-title":"Alzheimer's & Dementia"},{"issue":"1","key":"e_1_2_10_43_1","article-title":"FLAME: A Computerized Neuropsychological Composite for Trials in Early Dementia","volume":"12","author":"Brooker H.","year":"2020","journal-title":"Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring"},{"issue":"7","key":"e_1_2_10_44_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2176\/nmc.oa.2018-0318","article-title":"Long\u2010Term 4\u2009Years Follow\u2010Up Study of 482 Patients Who Underwent Shunting for Idiopathic Normal Pressure Hydrocephalus\u2014Course of Symptoms and Shunt Efficacy Rates Compared by Age Group","volume":"59","author":"Takeuchi T.","year":"2019","journal-title":"Neurologia Medico\u2010Chirurgica (Tokyo)"},{"issue":"7","key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical Diagnosis of Alzheimer's Disease","volume":"34","author":"McKhann G. M.","year":"1984","journal-title":"Neurology"},{"issue":"2","key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1080\/13854040590947461","article-title":"Does Impaired Executive Functioning Differentially Impact Verbal Memory Measures in Older Adults With Suspected Dementia?","volume":"20","author":"Brooks B. L.","year":"2006","journal-title":"Clinical Neuropsychologist"},{"issue":"3","key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1076\/1385-4046(200008)14:3;1-P;FT295","article-title":"Differential Impact of Executive Dysfunction on Verbal List Learning and Story Recall","volume":"14","author":"Tremont G.","year":"2000","journal-title":"Clinical Neuropsychologist"},{"key":"e_1_2_10_48_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102842","article-title":"Changes in Memory and Cognition During the SARS\u2010CoV\u20102 Human Challenge Study","volume":"76","author":"Trender W.","year":"2024","journal-title":"EClinicalMedicine"},{"issue":"12","key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/tbm\/ibac070","article-title":"Older Adults Can Use Technology: Why Healthcare Professionals Must Overcome Ageism in Digital Health","volume":"12","author":"Mace R. A.","year":"2022","journal-title":"Translational Behavioral Medicine"},{"issue":"1","key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1186\/1745-6215-15-508","article-title":"Characteristics Associated With Willingness to Participate in a Randomized Controlled Behavioral Clinical Trial Using Home\u2010Based Personal Computers and a Webcam","volume":"15","author":"Dodge H. H.","year":"2014","journal-title":"Trials"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.70451","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:11:49Z","timestamp":1783757509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.70451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,11]]},"references-count":49,"alternative-id":["10.1002\/acn3.70451"],"URL":"https:\/\/doi.org\/10.1002\/acn3.70451","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,11]]},"assertion":[{"value":"2026-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"acn3.70451"}}