{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:59:44Z","timestamp":1791197984900,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The genome\u2010wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329\n                    <jats:sup>A<\/jats:sup>\n                    to long\u2010term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329\n                    <jats:sup>A<\/jats:sup>\n                    might influence cognition in other neurological diseases and healthy controls. We explored the relationship between rs10191329\n                    <jats:sup>A<\/jats:sup>\n                    and cognition using reaction time, fluid intelligence, and prospective memory tests in the UK Biobank. We observed weak but directionally consistent associations between rs10191329\n                    <jats:sup>A<\/jats:sup>\n                    and poorer cognition in controls, with similar but non\u2010significant trends in Multiple Sclerosis, Parkinson's disease, and dementia. Our results support the hypothesis that rs10191329\n                    <jats:sup>A<\/jats:sup>\n                    might affect multiple sclerosis outcomes by affecting brain health.\n                  <\/jats:p>","DOI":"10.1002\/acn3.70458","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T07:15:34Z","timestamp":1782112534000},"page":"2143-2147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Multiple Sclerosis Severity Allele\n                    <scp>\n                      rs10191329\n                      <sup>A<\/sup>\n                    <\/scp>\n                    and Cognitive Function: A\n                    <scp>UK<\/scp>\n                    Biobank Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2913-0672","authenticated-orcid":false,"given":"Ioanna","family":"Zimianiti","sequence":"first","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health Queen Mary University of London  UK"},{"name":"Department of Neurology, Royal London Hospital Barts Health NHS Trust  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena","family":"Waters","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health Queen Mary University of London  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-7274","authenticated-orcid":false,"given":"Adil","family":"Harroud","sequence":"additional","affiliation":[{"name":"The Neuro (Montreal Neurological Institute\u2010Hospital)  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Human Genetics McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-0039","authenticated-orcid":false,"given":"Pernilla","family":"Stridh","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institute  Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2993-585X","authenticated-orcid":false,"given":"Ruth","family":"Dobson","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health Queen Mary University of London  UK"},{"name":"Department of Neurology, Royal London Hospital Barts Health NHS Trust  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