{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T02:47:06Z","timestamp":1782528426284,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Evaluate clinical and laboratory correlates of abnormal neurologic exam findings after acute HIV infection (AHI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants from the RV254\/SEARCH 010 cohort in Bangkok underwent standardized neurologic examinations at Weeks 0 (AHI), 12, 96, and 288 following antiretroviral therapy (ART). A subset of participants completed 3T neuroimaging. Associations between neuroimaging, clinical and HIV parameters, and abnormal neurologic exam were analyzed using chi\u2010square tests and multinomial regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At AHI, 703 participants (median age 26.5\u2009years, 97.6% male) had neurologic exams, with follow\u2010up data available for 493, 667, and 560 participants at Weeks 12, 96, and 288, respectively. Viral suppression (\u2264\u200950 copies\/mL) was 0% at Week 0, 65% at Week 12, 98% at Week 96, and 99% at Week 288. Abnormalities in any neurologic exam domain were observed in 26%, 28%, 17%, and 8% of participants at each time point. Most findings occurred in sensory and fine motor domains. During AHI, history of HCV co\u2010infection associated with abnormal exam (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). At Weeks 96 and 288, higher CD4:CD8 ratio correlated with abnormal exam at the same visit (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040 Week 96,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018 Week 288). In a longitudinal model, higher Fiebig stage associated with conversion from abnormal to normal neurologic exam (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.035). Of participants with MRIs, 14% at Week 0 and 36% at Week 96 demonstrated abnormalities; abnormal MRI at Week 0 associated with abnormal fine motor performance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Objective neurologic abnormalities are common during AHI, though few persist with long\u2010term ART. Coinfections, immunologic state, and demographic factors modify these outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.70467","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T02:25:49Z","timestamp":1782527149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Neurologic Exam Findings in People Diagnosed and Treated During Acute\n                    <scp>HIV<\/scp>\n                    Infection"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5884-9734","authenticated-orcid":false,"given":"Kathryn B.","family":"Holroyd","sequence":"first","affiliation":[{"name":"Department of Neurology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-8769","authenticated-orcid":false,"given":"Tyler","family":"Hamby","sequence":"additional","affiliation":[{"name":"Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Sacdalan","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation  Bangkok Thailand"},{"name":"Research Affairs, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somchai","family":"Sriplienchan","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathariya","family":"Promensa","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation  Bangkok Thailand"},{"name":"Research Affairs, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxenaree","family":"Poonpitak","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Netsiri","family":"Dumrongpisutikul","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e8ne","family":"Kroon","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Vasan","sequence":"additional","affiliation":[{"name":"Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Paul","sequence":"additional","affiliation":[{"name":"Faculty of Psychological Sciences, Missouri Institute of Mental Health University of Missouri\u2013St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferron","family":"O'Campo","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydie","family":"Trautmann","sequence":"additional","affiliation":[{"name":"Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Yale Center for Brain and Mind Health Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Spudich","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Yale Center for Brain and Mind Health Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the RV254\/SEARCH 010 Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001390"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16071082"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/313810"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365\u2010017\u20100548\u20106"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002837"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12981\u2010019\u20100257\u20108"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac466"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000616"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002831"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003496"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.43.10.2099"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102436"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw683"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1650"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003546"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i29.4846"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2019.1652728"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12981\u2010025\u201000707\u2010x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.19.1.20697"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu669"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix466"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13621"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.04.024"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.70467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.70467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T02:25:50Z","timestamp":1782527150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.70467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":23,"alternative-id":["10.1002\/acn3.70467"],"URL":"https:\/\/doi.org\/10.1002\/acn3.70467","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"assertion":[{"value":"2026-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"acn3.70467"}}